Right, so roughly 9 months ago I came up with an idea for a drug magazine to cover stuff that recreational drug (ab)users would find helpful, informative, and entertaining. There are plenty of weed magazines, but not much that covers other subjects; at first I thought there were zero zines or publications like this but there are a few, including one done by Erowid. It was only a passing idea that I came up with while in rehab and posted on the forums of Chemphoria, not thinking much of it. People took to it, and so we set it up some article ideas, got some people working on it, and came up with some cool ideas, art, articles, etc.

There were many delays due to every god-awful reason in the book, but at the final stages of production (i.e.; putting it into an actual zine form using software, which no one knew how to use) it was basically abandoned due to inter-forum/IRC channel politics. I won’t bore you with the details, but I basically up and left and have all the files, information, emails, etc that’s needed to continue it. I’ve always reasoned to myself that there’s no need to protect against plagiarism since no one could ever follow through; no one could ever write a sequel to something I started.

And so we get to the point: I am in possession of several articles and various pieces of art work that could make a very awesome first issue of a zine, but I am not going to put it into zine form. At least, not yet; it’s too involved and I have too little support. However I still feel the authors deserve some credit, and needless to say certain articles are fairly relevant enough that they’re getting posted anyway (see: NoWarning’s opiate potentiation guide). I was going to try to put them into some sort of wiki format, but that was a total clusterfuck.

Failing everything else, I’m just going to post them here, and declaring that Dose is still mine. Specific authors, if they want to say, “I don’t want you to use my article” are fine to tell me to take it down; I doubt however that anyone cares about such petty internet politics.

Enjoy.

­The Complete Idiot’s Guide To Getting a Bunch of Weird

Monsters to Wait in Empty Rooms

& Do Your Bidding

Proprietor: The Happiest Little Nug

There are many things that we, as humans, would like to accomplish in life. Getting high, finding love, discovering the secrets of the universe, all fine and upstanding goals, but when it gets down to it what do we all really want? What do we all crave? Smack? No good sir, the answer…well the answer was power, and few things in this life command more power and clairvoyance than getting a bunch of weird monsters to wait in empty rooms and do your bidding. Why you might ask? Well, what if someone was to come along looking for you? Tell them to fuck off? No, this is much too arrogant of a task. Instead leave monsters loyal to you and only you in every room you might be in or ever want to be in. Here’s where we get to the meat of this article, how exactly do you go about mind control? Well all sorts of drug concoctions have been tried by just about everyone to control populations of humans, animals, anything barley alive really, but only one really stands out. Scopolamine, the infamous tropane alkaloid from the Datura family, is that drug. Subjects under the effects of this drug have been know to:

1. Follow every command to the T no matter how ridiculous.
2. (See A.)
3. (See Saw)

Anyway a fairly simple process can be followed to do a home extraction. Well what are you waiting for? The secret of mind control is contained in the rest of this article! Aren’t you excited?…..not even a little? You will need: At least 10g of dried, ground datura plant material, NH4OH, H2SO4,petroleum ether and diethyl ether, NA2SO4, distilled water, and whatever lab equipment you deem necessary.

Wet your 10 grams of datura with 15 ml of NH4OH. Then add 300ml of ethyl acetate and let it sit at room temperature for 72 hours. Filter the extract and evaporate your solvent. Dissolve the residue in distilled water and acidify with H2SO4 to around 3-4 PH. Then extract with petroleum ether and diethyl ether to remove lipophilic, acidic and neutral material. After basifying the solution to PH 9-10 with your NH4OH, extract with chloroform and wash with distilled water and dry with NA2SO4.

Now that you’ve done all that I’ll tell you how to identify a common datura plant that grows world wide. Odd that I tell you this after the extraction I know, but I’m assuming if your serious about being an idiot you’ll have read this at least once before trying it. What you’re looking for is know as Datura stramonium it grows like a woody, leafy bush and it smells nutty. Its leaves are soft, irregularly undulate, and toothed. The flowers are trumpet-shaped, white to creamy or violet, and 2 to 3 inches long. The egg-shaped seed capsule is usually covered with spines. Or if you prefer growing your own seeds are available from many online ethno botanical sources. Bouncingbearbotanicals.com and ktbotanicals.com to name a few.

Feel up for some history? Datura was used medicinally by the Zuni, Aztec, and Mayan peoples. It was used to treat many aliments such as bruises, minor wounds, skin ulcers, hemorrhoids, Arthritis, rheumatism, and general swelling. Scopolamine happens to be an excellent bronchial dilator meaning it can alleviate asthmatic symptoms and other pulmonary conditions, Recreational datura usage is known to have occurred since 2500 B.C [olmec shamans]. The herb is used today in many manhood and divination rituals in Africa, India and China. The drug is also used medically today under the name Transderm and Scopace. They are used to relieve nausea, vomiting, and dizziness associated with motion sickness and recovery from anesthesia and surgery. Scopolamine may also be used in the treatment of parkinsonism, spastic muscle states, irritable bowel syndrome, diverticulitis, and a whole mess of other things, but I think you get the picture.

Fun Facts: Dose 10 mgs orally for your first to see where you stand with this drug. If you overdose on scopolamine or choose to dose above 80mg (they’ve happened with less) please obtain the antidote first, Physostigmine. 1-2 mg IV given slowly should be enough, but you should probably call an ambulance anyway.

Don’t become a statistic. Don’t use scopolamine if you have or suspect having kidney disease, liver disease, an enlarged prostate, difficulty urinating, a stomach obstruction, heart disease, bladder problems, or glaucoma. DO NOT EYEBALL DOSES, DO NOT DRIVE, DO NOT GO TO WORK, DO NOT ROB/RAPE/KILL ANYONE(at least, no robbing or raping or killing without a doctor’s prescription).

Holy Fuck It’s a Coma, Get in the Bed!

OR:

What not to do with a bottle of cough syrup

Delivered in Morse code by JoePedo

A short time ago, an individual wrote to us with the following account of a curious experience:

Okay, so about 6 months ago, I almost died, and I’ve always wondered what happened, what chemical combination caused it.I was in a field drinking Sparks (caffeinated beer) with a good friend. I had drank about a bottle and a half of Delsym around 12 hours earlier. So I only drank like 2 Sparks (and at this point i was a heavy drinker), and then I blacked out. From what I heard, I was sort of in a coma, I pissed myself, my nose was bleeding, i was mumbling real bad and I couldn’t fucking walk at all.

- “Skitzy,” via an internet message forum.

Shortly thereafter, an individual going by the name of “Ford Prefect,” a community-respected chemist, noted the following observation:

Quote:

415 ml of dextromethorphan polistirex would be about equal to 2500 mg of DXM HBr.

Yet, at the end of this exchange, no one in the discussion was yet aware why such a low volume of ethanol would precipitate a total coma. Regrettably, a short time later, a moderator shut down the discussion, mistaking it for a discussion of single-receptor antagonists rather than a complex discussion of molecular neurobiology.

So WTF happened, d0nnar?

On its lowest possible stages, neuroscience is a very fascinating thing. Some of our readers may have a background in electronic logic processing on a hardware level, and essentially, neurobiology functions in essentially the same way. Virtually every individual neuron can be considered to have an ‘upstream,’ and a ‘downstream.’ Similarly to transistor logic circuits, each upstream input, or downstream projection, can have an excitatory, or inhibitory, influence on its own downstream secondary transmission – similar to the functions of such components as AND &  NOT gates in transistor logic.

Of course, any study of molecular neurobiology or monocellular electrochemical neurology would be incomplete without a study of neuroanatomy. In this paper, we put forward the hypothesis that the woeful tale of “Skitzy” is not one of dextromethorphan, but one of noradrenergic enervation of the entire CNS mass.

Don’t Eat the Blue Microdot / the Blue Microdot is my Friend!

Noradrenergic neurotransmission in the CNS, much like 5-HT neurotransmission, is an organ-centralized affair which enervates the entirety of the remaining CNS from a central body of control. In humans and the majority of things whose central nervous systems are even distantly related to them, that center of control of noradrenergic transmission is known as the locus ceruleans.

Some of you may be familiar with the term “locus” from such terms as “genius loci” or “locus of control,” while the more metrosexual among the readership [we have those? –ed], with their background in interior decorating, will almost certainly recognize “cerulean” immediately. That’s right, dear reader – an entire discipline of science named an entire organ of the brain “the blue spot,” and one of the great joys of study in the sciences is learning a little Greek and Latin and discovering just how slightly cracked and loopy your counterparts and predecessors are. Since we live in an essentially preliterate society, no one reads this stuff, and so science continues in a culture which might best be euphemized as “unsupervised,” in which someone has an eight year old boy who is close to them arbitrarily name their random number, calls the fundamental particles of the universe by a nonsense syllable in a poem from a work which most resembles one of Dodgson’s love-sonnets in the seriousness of its tone, and start referring to such serious and weighty matters of the brain as “the blue spot” and “the black stripe” when they think no one speaks Latin. Charming fellows, really, the sort of folks you love to take to parties in the hopes of getting them drunk and all.

But, for the moment, the main things one might need to know about the Locus ceruleus, this strange blue place, is that it controls noradrenergic transmission, and that it has outgoing projections to essentially every other part of the brain – it’s downright famous for its long neural projections, in fact. As for the locus ceruleans’ noradrenaline itself, we note that hypocretin-signalled neurotransmission relies heavily on noradrenaline for initiation (see Grivel, 2005), and that subsufficient hypocretin/orexin transmission is heavily implicated in abject narcolepsy (Mignot, 2000).

NORLY, WTF happened, d0nnar??

Remember above, where the basic structure of neurotransmission – upstream and downstream release in the cascade inducing inhibitory and excitatory effects – was elucidated?

Well, we propose that what happened was very simple. GABA is already known to be central to inhibitory gating of the locus ceruleans (see Ennis, 1989, for more info), while NMDA glutamergic neurons are entirely charged with the hyporexin-mediated exciatory effects which noradrenaline holds on consciousness – those interested in further reading may wish to review the appropriately-titled “Excitatory Effects of Hypocretin-1 (Orexin-A) in the Trigeminal Motor Nucleus Are Reversed by NMDA Antagonism,” whose title is suggestively reminiscent of “Schitzy’s” claims.

In short, we propose that the individual known as “Schitzy” utilized 2.5 grams of the n-methyldextroaspartate-sensitive glutamergic receptor antagonist dextromethorphan, along with the introduction of the broad-spectrum GABA agonist ethanol, specifically and surgically induced the total separation of the consciousness-excitatory pathways of the locus ceruleans from their neural tissue via the absolute inhibition of all upstream and downstream pathways, resulting in immediate and total coma.

Conclusion

We believe the case of “Schitzy” illustrates a need among the community of consumption of bioactive molecules for a greater degree of education in human physiology, specifically including molecular neurology, neuroanatomy, and familiarity with the cytochrome p450 systems. No responsible researcher would advocate the complete and total excision of an entire organ’s contact with surrounding brain tissue in a healthy human being, and even of the most passing of familiarities with the effects of these drugs on consciousness activation systems would have had some chance to have predicted the potential excision and disintegration of neural signaling, to the point where ethanol-induced loss of consciousness and Ca++-mediated neurotoxicity in amphetamine use are openly discussed in their respective lay communities. We believe the burden of education and knowledge regarding the actions of neuroactive compounds lies with anyone seeking to consume them, rather than with police, parents, manufacturers, or worst of all, a government which has already woefully failed in total drug education misinformation, and consider the cultivation of a sense of neuroresponsibility among the community to be the leading health issue of importance for our society. Bioactivity is no respecter of lines of legality or illegalities – both cinnamon and sage synergize in their actions to lower the seizure threshold, for instance, in pathways similar to the ones noted here – and a sense of knowledge as the duty of the responsibility which is a prerequisite of consumption is of vital importance to cultivate for our age.

(I’m not sure whose picture that is, but it’s awesome regardless)

NoWarning’s New & Improved Opiate Potentiation Guide

The scene: a twenty year old junkie rushes back to his hell-hole of his apartment, buzzing with anxiety to get his fix. Contraband in hand, he opens his door, and even as he makes contact with the doorknob he knows. Fuck…I’m short. This isn’t going to get me high…He rushes in, prepares his shot, hits his favorite vein, sinks to the floor as the rush hits him. Five minutes later, our junkie is raging, fuming – a veritable wild-fire of opiod rage. Slowly, he sinks to the floor, wondering what to do, in fact, what is there to do? That is, besides…

Opiod Potentiation

Now that we’ve set the scene and have got some opium-based-alkaloid drama going. Follow this formula and rest assured, you will be hypothetically nodding, but of course you won’t since no one does drugs if they aren’t prescribed to you by a qualified physician. Right? Good.

But before the climatic new edition of N0 W4RN1NG’s “patented” opiod potentiating recipe, first let’s engage in a bit of foreplay. Explanation time, divided into classes:

Antihistamines

Antihistamines are common drugs that have been well-known to enhance the effects of opiods. By definition, an antihistamine is any drug that inhibits the release of, or the actions of histamine. They tend to increase sedation in most and euphoria in some, and have the added benefit of reducing itching. This is because histamines are released as a response to allergens and other itch-causing sources. There is, however, some debate over which type of histamine is superior for combating itch. H1 receptor antagonists (classic antihistamines) are generally believed to be the best for combating itch and inducing sedation – our current goal. H2 receptor antagonists are thought to have, at most, a slight effect on both itch & sedation, whereas H3 actually has an opposite effect. Apparently, the superiority of H1 receptor antagonists lies in its mechanism of action, which was studied over a decade ago:

“These effects of neuronal histamine upon cortical neurons are likely to affect synaptic transmission in several ways. The depolarization per se should increase the likelihood that excitatory synaptic potentials will evoke an action potential. The increase in whole-cell input resistance evoked by H1 receptor activation should make the cell more electrotonically compact, thereby altering its integrative properties. We hypothesize that these mechanisms would allow histamine, acting at cortical H1 receptors, to enhance behavioral arousal. During waking when histamine release is highest, blockade of H1 receptors by systemically administered H1 receptor antagonists would be sedating.”

- Reiner PB, Kamondi A, “Mechanisms of antihistamine-induced sedation in the human brain: H1 receptor activation reduces a background leakage potassium current.” Neuroscience. 1994 Apr;59(3):579-88.

.

In the realm of personal experience, I would have to say that, as a general principle, the ethanolamine class of antihistamines is the most effective at boosting the desired effects. Particularly, phenyltoloxamine is my personal favorite of the over-the-counter antihistamines. You won’t find it a solitary drug – it only appears in combination formulations with aspirin or other salicylates (or acetaminophen), but a dose of 60-90 mgs of phenyltoloxamine is a solid way to boost any opiate experience. Unlike other antihistamines (*coughCPMcough*), it doesn’t dominate the opiate high as much.

Other prominent antihistamines include the classic diphenhydramine (at a dose of 25-50 mgs) and DPH’s mother, dimenhydrinate. As a slight digression, dimenhydrinate is cleaved into the caffeine relative, theophylline, so it in theory might be more useful than diphenhydramine alone – this could counteract the drowsiness to some extent. Besides those prescription antihistamines, doxylamine and elemastine are the other options, however they’re nothing special.

As far as the prescription antihistamines go, ophenadrine is (in my opinion) the best, although it is not that much better than OTC phenyltoloxamine – it does seem to be a good bet, though. Coming in a close second and third place, hydroxyzine and promethazine are damn good non-enthanolamine prescription antihistamines. On a related note, the piperzine Meclizine is over-the-counter and very useful at combating nausea (cannabis will always be the best at this, though). It’s a good drug to take if you’re not sure of your tolerance and are prone to opiate-induced projectile vomiting. Bleeeechhhhh. Lunch, all over the walls. No one wants this…

The other commonly found antihistamines are chlorpheniramine (CCC) and Brompheniramine (Dimetapp). I have personally come to dislike chlorpheniramine, but if it’s all you have than it is better than nothing. Do yourself a favor, though, and cap your max dose at 4 mgs. Brompheniramine is nice, but not nearly as effective as the ethanolamine staples.

Dextromethorphan (DXM)

Sigma agonist, NMDA antagonist, nicotinic receptor antagonist, serotonin releaser, dissociative anesthetic, tolerance reducer, and high potentiatior – dextromethorphan is all that and probably more. Brain chemistry is complicated, to say the least. DXM is however, also the easiest way to turn a smooth and clean oxycodone buzz and drench it in dirty weirdness. I usually recommend only taking 30 mgs of DXM, and would definitely cap the dose at 60 mgs. At 30 mgs the effect is barely noticeable, but at double the dose one might begin to feel slightly different, detached.  A small warning: DXM does synergistically depress respiratory functions when used along with opiods. Taking 60 mgs with an already strong dose can be a bit dangerous, although it isn’t very likely.

Antacids

Having a basic(high) pH in your stomach has been shown to enhance opiod bioavailability when consumed orally, as well as the rate of absorption. Taking a tums or two, baking soda or even magnesium oxide/hydroxide an hour or so before you ingest your opiate of choice will have possibly dramatic effects on your experience, depending on the usual pH of your stomach. And, speaking of magnesium…

Magnesium

While magnesium oxide is a great agent for basifying the stomach, but as a sole source of magnesium, it’s fairly – excuse the technical jargon – shitty. Taking approximately 400-600 mgs of magnesium citrate, taurate, glycinate, or as a chelate will enhance the experience. Like DXM, magnesium is an NMDA antagonist, which can mean many things, but in this case it means that it can aid in preventing the build up of the much dreaded opiate tolerance. Also, high doses of magnesium can have a mild sedating effect, which of course blends in nicely with any opiate buzz. Expectt mild laxative effects, as well.

Carisoprodol (soma)

For whatever reason, Soma, (and its active metabolite, meprobamate) are extremely useful in enhancing the opiate experience. A dose even as low as 200 mg of meprobamate or 350 mg of carisoprodol will have a very positive effect on your high. Take them at the same time if you are eating your opiate, or twenty minutes before hand if you’re railing it or shooting it. They have a pretty long half life, but the sought-after-effects seems to only last four hours, max. They are Rx only, and meprobamate is rarely prescribed these days – but Soma is easy to find on the streets and the internet of course contains anything and everything. If you know where to look…

Dopamine Precursors

The amino acids phenylalanine and tyrosine are necessary to create dopamine in the brain. One of the wonderful effects of opiates is that they indirectly raise dopamine levels in the brain. That means that, theoretically, having some of dopamine’s direct precursors abundant in your brain will lead to increased plasma concentrations of dopamine in the presence of a dopaminergenic drug.

DL-phenylalaline at a dose of 1000 mg seems to really ramp up the energy and euphoria when taken at 500 mg, 30 minutes before ingestion) and then another 500 mgs ten to fifteen minutes later. Also, 250-500 mg of n-acetyl-tyrosine has similar effects.

I’ve found that, similar to how MDMA connoisseurs will preload with 5-HTP or l-tryptophan, noticeable effects can be achieved with opiates by preloading for a day or two beforehand with DLPA. Tyrosine should work as well, although I have no personal experience with it.

Caffeine

In addition to offsetting drowsiness, a modest dose of caffeine will prep the brain for optimum dopamine production. This is especially important if you took dopamine precursors, and as such taking energy drinks full of strange herbs is advised against [who knows what interactions are possible - maybe impotency, or chemical lobotomies – ED]. A cup of coffee or tea should do the trick. Now on to the real fun stuff…

Enzyme Inhibition & Manipulation:

Before diving in, some basic primers on the subject: codeine and codeinones (hydrocodone, oxycodone, etc) are generally handled by two main cytochrome P450 enzymes: CYP3A4 and SYP2D6 (as well as glucoronidation). CYP3A4 processes your fun little friends into boring geeks like (mostly) inactive norcodeine. CYP2D6 metabolizes the goods into some really wild stuff like hydromorphone, oxymorphone, and such. So with codeine related drugs, you’re going to want to “clog” up the enzyme CYP3A4 to ensure that as much oxycodone or what have you is A) not processed into an active metabolite and B) come up on a little extra oxymorphone.

White Grapefruit Juice (Concentrate)

Yes, the cheap stuff. Make sure it’s 100% juice and that all of said juice is white grapefruit juice. A few studies have shown there to be significantly higher levels of 6-hydroxy-bergamottin, the main CYP34A inhibitor in white grapefruit, which is in the ghetto-cheap-concentrated juices as versus the freshly squeezed kind. I’m certainly not complaining…

Additionally, white grapefruit juice is, for whatever counter-intuitive reason, actually a base once inside your stomach. Which means it actually raises pH once inside you, similar to what a Tums would do. A tall glass or two of this stuff an hour before ingesting some opiates should suffice.

Tagamet

Tagamet HB (cimetidine HCl) is an OTC broad range CYP450 inhibitor. It inhibits 3A4 and 2d6 fairly well, although not nearly as well on 3A4 as well as white grapefruit does. This makes it ideal not only for oxycodone and hydrocodone, but also morphine & its relatives. Miss morphine and her brothers and sisters heroin, hydromorphone, etc, get converted into inactives by 2D6 and also by a process known as glucuronidation. Tagamet and white grapefruit juice work very well with oxycodone and hydrocodone, together they prolong the high and intensify the peak. With heroin and hydromorphone, white grapefruit juice doesn’t seem to effect it much at all, and tagamet has an effect similar to but lacking in the intensity as with hydro or oxy. The sweet spot in my experiences has been 600 mg, an hour before dosing.

Quinine & Quinidine:

Quinine is the ingredient that gives tonic water that taste that’s so bitter and well, toniclicious. Did I mention that fact that it’s a mild inhibitor of CYP2D6? A couple of glasses of tonic water an hour or so before your heroin/morphine/hydromorphone will lengthen the buzz, especially combined with tagamet. Because tonic water is acidic, if you plan on eating your morphine/heroin/hydromoprhone (which is stupid – the oral bioavailability on all of those blows), you need to take Tums with your drink to counteract the acidity.

Wellbutrin (bupropion)

Wellbutrin is, in this writer’s opinion, one of the best fucking morphine potentiators out there. It is an extremely strong CYP2D6 inhibitor , and it also has some mild dopamine reuptake inhibitor and stimulant properties of its own. Approximately 100 mg taken orally [fun note: people have reported cocaine-like rushes when injecting bupropion – more on that next issue! – ed] before your morphine or morphone will significantly lengthen the effects as well as adding a bit of stimulation and extra euphoria to the experience.

Glucoronidation

Here we have something brand new, as far as I know no one has yet attempted to inhibit glucoronidation in an effort to enhance opiate effects. I’ve thrown around CYP450 inhibition for a while now, but it always bothered me that whil eeffects are definitely present, they are not as strong as they theoretically should be if you were really clogging all exit paths for the opiate. Then I realized that a good portion of most opioids (especially morphine) is handled by a separate set of enzymes, enzymes that conjugate opiates to an inactive glucoronic acid salt. I didn’t know much about these at the time, so I lost interest and forgot about them; recently, however, I stumbled upon the concept of glucoronidation inhibitors – theoretically, in combination with CYP450 inhibitors, glucoronidation inhibitors would provide extreme lengthening of the opiate high.

And yes, they do exist.

Opiods like oxycodone are primarily glucoronized through a fun little guy called UGT2B7, unfortunately there are not too many OTC inhibitors of our friend. Or at least, that I’ve found  [submit anything you find to dosezine@gmail.com if you please – ed] – though the two that I found are laughably enough quinine and naproxen. Apparently, super human dosages of naproxone and quinine would be necessary to precipitate a noticeable effect on UGT2B7 inhibition. The inhibition would be synergistic so both should be used at once. Based on preliminary research, you would have to drink something like a bottle of tonic water along with roughly 800 mg of Aleve. This amount of naproxen is sometimes prescribed for acute pain management, but may not be safe for everyone. Do not drink alcohol with this combo and avoid APAP (acetaminophen) out of principle.

That said, to get the ABSOLUTE MOST out of your opiate, try N0 W4RN1NG’s (brand fuckin’ new) patented opioid potentiation formula:

* T-60) 600mg Tagamet HB(Cimetidine HCl), 1000mg DLPA OR 500mg N-Acetyl-Tyrosine and a large glass of (white) Grapefruit juice, preferably from concentrate. Add in an extra strength tums or 1.5tbsp. of baking soda if you are going to be eating your opiates.
* T-45) 30mg DXM HBr, 90mg phenyltolaxamine citrate, 600mg Magnesium citrate\taurate\glycinate\chelate
* T-20 A bottle of tonic water (quinine), 880mg Naproxen Sodium. A cup of coffee, or a strong black tea. Take another tums now if you’re eating your opiate to counteract the tonic water
* T-0) Parachute\chew\rail\bang your opiate
* T+10) Smoke a bowl or two. Not more, you don’t want to over power it.

Note: the author bares only a passing resemblance to Terrence McKenna.

DMT Primer

Revealed to Scovenger by hyper-elves in the 9th dimension

N,N-dimethyltryptamine (DMT) is a hallucinogen found endogenously in human brain
that is commonly recognized to target the 5-hydroxytryptamine 2A receptor or the trace amine–associated receptor to exert its psychedelic effect.
It’s found in many plants, but the main source of it for recreational use is the plant mimosa hostilis, an evergreen shrub that naturally grows
in Brazil, but can be mail-ordered from many places.
Caution must be exercised with it though; used properly it can be one of the strongest psychedelics, actually no scratch that, pure connection to the spiritual
underworld of energy, and this energy must be respected and flow in the right directions.

Extraction:
There is a common method that you can find named the ‘lazy mans tek’, google the term, it’s very simple to do, you just need ground mimosa, water, lye and naptha,
all pretty easily available .. All I would add to this is that instead of evaporating, use a small volume of solvent (approximately 20ml/100g mimosa), and once you have
separated it, put it into the freezer at as low a temperature as it will go, and leave overnight. In the morning you should have some beautiful crystals sticking to the sides
of your container. This works by the principle of freeze precipitation; the solubility of DMT in your naphtha drops rapidly as it gets cold. Moving quickly to avoid it
dissolving again as it heats up, pour the naphtha through a metal coffee filter to catch any spare crystals that have fallen off, and air dry your crystals to avoid any traces
of naphtha. Believe me, smoking naphtha is NOT any fun. Scrape them up and collect, store them in a freezer to avoid them degrading in heat and light.

For the actual experience:
Let me start with saying; nothing will really prepare you for it, but if you educate yourself on it as much as you can then there’s not much risk.
The essential part of it really is to just ‘go with the flow’, no matter how stereotypical it sounds it is true. Before the trip it’s pretty usual to be pretty anxious,
I always make sure I’m clean, in a good temperature room, not too hot or too cold, take a piss
beforehand just in case you get scared .. some quiet soothing music can be good, but other times it can just be very irritating. Lighting doesn’t matter
a huge amount, just make sure it isn’t too harsh light, and bright sunlight can also be irritating to the eyes sometimes. Take a few deep breaths, relax,
and inhale deeply. Hold it in for as long as you can, then gently exhale. At this point you’ll feel it coming on strongly. Usually the anxiety disappears soon after,
and you go into it. It WILL be powerful, totally unlike anything you’ve ever seen before. From there on you should
be able to take care of yourself inside your mind. Try and keep your eyes closed as it leads to much more vivid visions, but open eyes can work ok as well.
In some ways it’s good to start with a low dose to get yourself used to the feeling, but others may just want to plunge straight in to be totally awed by it.
If you do manage to see elves, or entities, RESPECT THEM. One last thing, you may get the feeling you’ve shat/pissed yourself, don’t worry, you’ve not, just ignore it.

Many complain about the taste but TBH as long as your DMT is pretty clean, it isn’t THAT bad, although very dry on the throat.
A bong will help immensely, smooooth and allowing you to take big hits, but filters out a small amount of the active ingredients.
You want to get all of your dose in quickly, less than a minute/until you can’t take any more sort of thing. A typical ‘base pipe’ also works very well, find one with a large
chamber to take big hits quickly.
As for how to smoke it, I’ve found it can work pretty nice using an ordinary pipe or bong, with a bit of a brillo pad underneath, and a metal screen on top.
Hold the lighter about 1″ away from it, heat very gently as it doesn’t take much heat, and inhale deeply.
But, a vaporiser will work much nicer, although harsher, get a base pipe and use that.
PS: Make sure not to use the same paraphernalia for dmt and weed unless you want to be slightly tripping every time you get stoned, again believe me that is not nice ..

Don’t do it too often or it can mess with your head, and be in a calm atmosphere where you’re sure nobody will disturb you.
Use a trip-sitter if you wish to, but they’re not 100% necessary.
A nice woodland/lochside environment just after dawn on a summers day would be perfect IMHO.

Make absolutely sure you weigh it correctly. 20mg will have you definitely feeling it, but will feel quite empty and won’t ‘go anywhere’, around the 60mg mark is where you can
properly ‘break through’ out of reality and into your full-on experience, however it won’t be nearly as vivid and real as if you took 100mg. Be aware of what should happen,
and scale up your doses slowly so you’re familiar with the mindset it puts you in. Use a good digital scale with a MINIMUM resolution of 0.01g, although a milligram scale would
be definitely preferential.

Some make comparisons to other drugs such as salvia. In some ways they’re half-similar with their total uniqueness and length of duration etc, but they’re TOTALLY different tbh
.. DMT is EXTREMELY spiritual, energetic and glowing, sacred, totally undescribable while salvia is just total mindfuck-drab coloured-dysphoric-alter reality sort of thing.

Better than Laughing Gas

Written in a meth-frenzy by Killing

Xenon is a gas typically used in “neon lighting” and when excited by electrical discharge, xenon emits a blue glow. As a result of its increased luminosity and direct light flow, xenon is often preferred in luxury car headlights – as opposed to less exotic, halogen bulbs. Neon lights could be the source for this anesthetic gas that closely resembles nitrous oxide, with some major differences.

When used as an anesthetic, xenon is said to be an almost ideal agent; xenon is a colorless, odorless gas that causes no irritation to the user, and is also non-toxic and has proven to be hypoallergenic. By having low blood-gas coefficients, which is the gaseous equivalent of solubility, the effects of xenon are rather rapid. It can produce unconsciousness, analgesia (pain-kill), and muscle relaxation. It does not cause any profound respiratory depression, and is cardiac stable. “Xenon anesthesia produces the highest regional blood flow in the brain, liver, kidney and intestine”  This means that the heart and brain are not put under any excessive strain.

Since it is a noble gas, and as such requires extreme conditions to react with other elements, it is not metabolized in the body – it can be reused to achieve the initial effect. The xenon one inhales is identical to the xenon which one exhales, and it is easy to store since it is stable and nonflammable. The only problem with xenon is its prohibitive price; it is very expensive and can only be used efficiently through a recycling system.

Recreationally, xenon has a lot of potential. It is said to be one and a half times more potent as an anesthetic than nitrous oxide (Critical Care Medical Journal). Trip reports speak of vocal distortion, head rushes, and similar actions to nitrous oxide. Recreational use has not been pioneered to any great extent yet, despite xenon’s enormous potential as a recreational drug. It owes much of that to its high cost and obscurity.

Dosing xenon accurately can be tricky, to say the least. A trip report on Lycaeum stated that the user took a 50:50 mix of xenon / oxygen, and anesthetic sites state that a mixture of 70:30 produces full analgesia with amnesiatic effects. So going on a 50:50 mix would be wise for calculating doses. The average lung capacity is 5L, so a dose of xenon, using the 50:50 dose, would be about 2.5L. While these dosage ratios are very important for long term exposure, xenon gas may be treated as nitrous oxide. A balloon full of xenon will more than cover it. Just make sure to also take a break every few minutes, oxygen deprivation is not a good thing. Since it is not metabolized, the user can exhale back into the balloon and reuse it.

While xenon is available online or through mail order from industrial gas suppliers, it is very cost prohibitive. The smallest quantity available is a 25L tank for $485.00. Larger, industrial sized tanks can bring the cost down to around $10/L, which is roughly half the price for lower quantities.

Since xenon is an inert gas, when exhaled it is unchanged. A recycler system can be made with a few cheap items. The body only metabolizes 4-5% of the oxygen breathed. So you will exhale oxygen, carbon dioxide, and xenon (assuming you are using pure oxygen and xenon). Carbon dioxide is easily filtered out using a CO2 scrubber. The basic principle of a CO2 scrubber is that CO2, when mixed with water, forms carbonic acid, which can be neutralized by exposing it to a strong basic agent, like NaOH (lye) or KOH (caustic potash) and hydrated lime. Oxygen is easily absorbed using an oxygen absorber, typically found in food packages. Just remember, if they are exposed to the open air, they will only last around 20 minutes because they are absorbing all the oxygen in the air.

Xenon may also actually possess a medicinal value. It has been shown to have neuroprotectant qualities. This means that xenon can help block out any harmful chemicals that can damage nerve cells. Xenon may help reduce “… ischemia-induced brain damage…” (http://www.ionchannels.org/showabstr…?pmid=14526227) Ischemia induced brain damage is damage that occurs because of restricted blood flow. Amphetamine & related chemicals are vasoconstrictors, thus blocking blood flow, thus the connection is made that xenon may help with (meth)amphetamine toxicity.

Additionally, xenon has, “beneficial effects on ischemia-induced neuronal death and amphetamine-induced sensitization.” (http://www.ncbi.nlm.nih.gov/entrez/q…uids=16179534). Since the Xenon can reduce damage caused by lack of blood flow, any vasoconstrictors neurotoxicity could be partly reduced by using xenon. Damage done by cocaine, MDMA, amphetamine, and methamphetamine may all be much more controllable through the use of xenon…
More to come, later.

Any information or experiences you have with the only noble gas that will get you high? Send them to dosezine@gmail.com !

The author claims that, “Charles Manson is just misunderstood.”

The Injecting Pills Safely Dance

Written by Killing using brain-waves

NOTE: Injecting pills is not recommended! Injecting anything non-medical is not recommended! However, we know that it’s going to happen. I do it myself. If you do inject pills please follow these guidelines as a means of harm reduction, although by no means take this as a guide to making your injecting experience “safe”. No matter how you do it, recreational IV drug use never falls under “safe”.
I will first walk you though how to prep pills. I am basing this guide off of my experience with purdue oxycontins, roxicodones, and dilaudids. This guide will work for most other pills where the active ingredient is water soluble.
First get two spoons and wipe them down with isopropanol (IPA) –w hile you are doing this, wipe your fingers down. Crush/grind the pill(s) in the spoon. Add water. I typically add 1 and 1/2 as much water as I am planning on shooting.

Now stir the solution around – I usually use the orange cap from the syringe after I’ve wiped it with IPA. Drop a cotton ball in the spoon and suck up into a syringe. If you have wheel micron filters, use a slip tip syringe. Once you have the solution on the syringe put the micron filter on the end and hold the filter. Empty the syringe into your second sterilized spoon.
I like to do a wash on what remains in the first spoon. I add around 10 units of water and repeat the previous step, and now you have your solution in your second spoon add a little heat until right before it starts bubbling. I usually suck this solution up into a syringe without a cotton filter, or if I did not use a micron filter I use a smaller, tighter cotton filter.

Inject, and let the fun begin!
This method allows you to do a few things:
You filter twice
Your first filter is cold, which keeps out binders/fillers by playing with solubility
You do get to heat to sterilize your shot

Helpful Tips:
Your body will like more dilute shots. Use lots of water.
While this is a preference thing, Using 1cc syringes allows you to prep with a good amount of water. I recommend them.

Inject slowly! If your plunger is hard to move down, pull it out of your arm. You’ve most likely got a clogged needle. You do not want to inject that.
Having a good tourniquet is really helpful. Elastic ones work better than something with no stretch. Remember to release before you start injecting your shot!
Always register! If you are reading this guide you probably aren’t at the point where you can feel if you are in your vein or not! Injecting under your skin is not pretty.
If you feel any pain while injecting you are most likely out of the vein. Re-register to double check.
Always apply pressure to the injection site after you inject. It helps your body heal and will dramatically reduce track marks and bruising!
Be liberal with isopropyl alcohol. It is good to put on your hands, your equipment, and the injection site. Just be sure it has evaporated before you do anything!
MICRON FILTERS ARE HIGHLY RECOMMENDED!

Just another Sunday night with Kali.

Sent by Divine Messenger at the whim of Rizzo

Rizzo’s Sixth Circuit Psychedelic Circus

The experience of human consciousness has been accurately described to be divided into two groups of four levels. While this idea is certainly nothing new,
as all mystical & spiritual ideas are being constantly rehashed and recycled as they come to us from the furthest reaches of space (both inner and outer) -
Dr. Leary brought it into a more mainstream light. However, unlike some of his other ideas regarding consciousness and the expansion or exploration thereof,
the 8-circuit model will most probably not get you thrown into prison.

The subject of it is vast, as vast as consciousness itself. Discussing the intricacies of all the circuits would take volumes, especially as you go higher and
higher up. In fact, one could argue reasonably well that you could spend yr entire life trying to talk about the 8th circuit, the quantum circuit. Of course,
words will always fail one there. Which is why I have chosen one of the more mysterious, elusive, and -yet in my view, the absolute funnest circuit around. –

That view is entirely subjective of course, but I hope to share with you some of the delights of the sixth circuit.

Now, the concepts that I have regarding the 8-circuit model are not just parrots of what Leary, Robert Anton Wilson, Gurdijeff, and all the gurus and
teachers have put forth. There are basic similarities that everyone can agree on, but from personal experience I have to disagree with certain points. *This
will happen to anyone that attempts to think originally and creatively.*

First of all I think it is imperative to realize that there is no such thing as a pure experience on only one circuit. You’re constantly operating at all
levels at all the time, it is just a matter of focusing on one to reach the next level. For most people, talking about anything beyond the sixth-circuit is
just going to seem silly, as reality becomes so skewed and out-of-this-world that there is absolutely no way to have a steady reference point in relation to
our every-day world.

The sixth circuit is where a lot of progress is made concerning consciousness, awareness, spirituality, or what have you. It’s an awareness of your awareness
that lets you choose who you want to be. Some would argue that this falls more in the realm of the 7th circuit, but I disagree entirely. The 7th circuit falls
more in the realm of the realization of Self, or the union of paradoxical opposites (yin/yang). All of that is still in the realm of the human, which the
8th circuit completely bypasses. However, that’s besides the point…

Say you’ve been a white, male dentist for the past ten years. You’re bored, dissatisfied, life has lost its flavor and you need to be revitalized. All of
your other circuits are fine: you have a home, you’re healthy, you’re financially stable, you love to learn and talk, you have a distinct moral/value
system…and every weekend you smoke so much high-quality cannabis that even the music on the radio sounds like a direct transmission of divine ecstasy.

But that only takes you so far. You want more. You’re mentally hungry for a new experience, a new ride, a new YOU. At this point some people have a mid-life
crisis, or convert to Christianity while crying about the pandas, or maybe decide that actually you’re homosexual. Who knows? But those kinds of rash
decisions rarely end well, they’re always the product of impulsiveness and irrationality that’s misplaced. I know what you crave. It’s deep inside yr bones,
your very marrow produces it and yr loins throb with the lust for it.

You want High Adventure. You may not realize it, but something inside you calls out for a wandering through sacred groves, calling upon hidden spirits. Or
maybe a trek through hellishly hot deserts and the shade of a hill. It’s not just a reconnection with nature, it’s a complete transformation of Fantasy into
Reality. Something out of a D&D role-playing adventure, except far more ballsy, and with far more purpose.

So are you ready then, brave adventurer of…wherever? Prepare yr mind to take in Rizzo’s Sixth Circuit Psychedelic Circus.

If done properly, you will no longer be the same person you once were. That is to say, nothing will be taken away, except for the boundaries of who you think
you can be. This is the arena of archetypal figures, of monks, mages, magistrates, emperors, kings, queens, gods and goddesses. And you can be any of those,
as long as you truly become them. You can not approach this in a strictly rational, logical manner. What will take place is a fluid, intuitive creation of a
new “character”, so to speak. View your life as a story-book, where everything is entirely mythic in scale.

Before setting out on yr adventure it is best to first immerse yrself in the spirit of that which you wish to become. Generally, I let the environment dictate
the archetype that I take on, I don’t try to force anything onto the experience. If you’ve been living in the west yr entire life and yr ancestors were all
Vikings raiders, it will be much more natural to take on the role of maybe Thor or Odin or some berserker out to rape, ravage, and pillage than an Eastern
samurai or monk or what have you. This should all be an expression of yr innermost love of fun, fantasy, and weirdness.

Reading fantasy or mythology can put one in the proper frame of mind, and give you a proper mental-vocabulary. Let’s say you, the dentist, wishes to become a
great viking warrior for a while. To do this you need to think of the world in the manner proper to that time – but not in a “historically accurate” context.
Remember, everything is now mythic, completely epic in scope. The Gods are involved in everything you do and take part of. Everything in nature is teeming
with secrets and mysteries. That cave that you pass by? It’s home to dark-elves – or dwarves – who for the right price will fashion you an artifact of great
power. But beware! Loki, the trickster, will be out to confuse you the entire time…

Okay, so now you have a feel for the spirit and the ambiance of the world you’re about to enter. But how do you break through? How can you really convince
yourself that this is taking place – especially in this day and age? All these artificial lights, machines, cars, noises, and what have you…It’s enough to
drain the fantasy and imagination out of even the most googly-eyed of seekers. I can not recommend anything specific, however I can tell you what works for
me.

Nothing will get you into the mood of adventure then really putting something at stake. Prepare yourself for a real adventure, load up a backpack with simple
items like food, water, etc, and other objects that have spiritual significance or are relevant. For example, as a viking warrior you should obviously have
some sort of weapon – but walking around with a gigantic axe is a sure way to get locked up somewhere. So perhaps carry a knife of legal size, or a walking
stick – anything that you can use yr imagination to turn into an item of power. Hills will no longer be hills, but the gathering-place of the fairy-folk. At
some places, at some times, and the in the right frame of mind, even rocks will tell you their secrets. It might be conducive to implement some sort of quest
into yr adventure so it is more than random wandering. Perhaps you’re seeking an object of power, the blessing of the gods, or secret wisdom which can only
be had in a certain location. There might be a medicine you need to find that is only available in a certain place. You can really mix-and-match this sort of
stuff with everyday reality, where cashing a check becomes the raiding of an enemy village.

So, you’re prepared. You’re about to go hiking off into god’s know where, with the right frame of mind, the right equipment, and the intent to breakthrough
into another self. But it’s not so easy, even if you’re already well versed in circuit-jumping. While I’ve found that long journeys will always do the trick
of breaking into that mythic feeling of god-hood, certain chemicals also help. Higher doses of DXM, mid-level dosages of mushrooms, low-to-mid-dosages of
LSD, and many other psychedelics can help. It will take some experimentation to get properly, but just about anything will work if you’ve prepared properly
and really set off on an adventure. The only real danger is perhaps going too far and landing in the 7th or even 8th circuit and not being prepared.

Practice makes perfect.

There’s no way to really describe what is going to happen to you, because it will be intensely personal and yet at the same time completely void of that
ego-self-personality you know as “yourself”. At a certain point you should get so lost in the thoughts and feelings of the Viking Wanderer named Ugarth that
you’ll completely forget that you were a dentist. Feelings of complete insanity, total detachment from reality, etc might start to overwhelm you. That’s
okay, we’re all crazy anyway. You’re just going crazy on purpose. But why?

To produce a shock. When you suddenly forget that you were a dentist, you’ll become Ugarth. But then you’ll remember that you forgot, so you’ll have to
remember you are – except that now you can’t relate to the thoughts and feelings of you the dentist. A sudden schism will occur where you are neither Ugarth
nor the dentist, and yet you are very much still you. It is at that moment, where you are neither one nor the other, neither up nor down, here nor there,
that you truly experience High Weirdness. Who am I? For that matter, WHAT am I, that I am able to change my self, have no self, and yet still at my very
essence always be my self? From there one can scale further on up into the 7th circuit of cellular & DNA/sexual consciousness, use the 6th circuit to modify
the lower ones, or just play around with your new self.

At this point, either reality will seem valid, so you’ll be able to deal with both realities as you know them with ease. Once you’ve broken through to that
level of uncertainty, Ugarth with naturally surface into your life. Having a viking warrior for a dentist could make for some very interesting interesting
conversations on the topic of oral hygiene. After all, a true viking warrior uses the blood of his enemies for mouth wash, and uses the fur of reindeer to
brush his teeth.

Life should be much more fun now, and far less serious. With creative imagination, some psilocybin, and an adventurous spirit, you can turn the most mundane
of tasks into something of truly epic proportions. Even studying at the library can be the intense search for hidden knowledge of a scholar or philosopher.
Most importantly, you won’t be clinging to those sorry ideas of who you think you are. Your entire self-image won’t be dependent upon these lame terrestrial
activities and useless business of busy-bodies that tell you that all to life is work, wife, and child.

No, it is no longer that way. Now you can look up at the sky as the sun-sets and say to your heart, “Tonight, I will take up battle against the Giants and if
I should fall, may the Valkyries take me to Valhalla. Nothing would be more honorable.” And as you get lost in the forest-park as you search for yr hated
foes, if the fairies should try to distract you and entice you into strange games and sweet pleasures…

Tell them Rizzo sent you, and that you are on a quest. Laugh it off. After all, this is the Sixth Circuit Psychedelic CIRCUS. Nothing is ever as it appears,
much less you. Take nothing seriously. Laugh with the might of one who is truly mythic in stature.

After all, is it not written, “I have said, Ye are Gods,”…?

Master Therion at his most attractive. Patron saint of &HE

Death, Dissociatives, and Dumbness

Written while in a serious ketamine funk by Rizzo

There is a strangeness which permeates the universe, a certain alien quality to the intelligence of this weird mix of life and death that we call an adventure. Or at least I call it an adventure, or maybe more correctly an infinite, never ending war. Either way, if I have indeed even split the ways (is there more than one?), the point is that I have found a way to harness this force. It now permeates me, everything I do, speak, write, not-do, think about, NOT think about, dream, awake, remember, forget, whatever, whoever, whenever…why ever. Why, indeed? Without the question there can be no answer, and without a self there can not be another.

So really, perhaps what I’m getting at is that there is no separateness from this strangeness of which permeates me and everything – or rather there is no “me” but there is strangeness and a universe, in other terms there is only a “me” that is an infinitely strange universe. If you’re confused, well, welcome to my world. There’s nothing in it except confusion & strangeness. Sorry to break it to you, if you were expecting a circus and fireworks you should just load up on some dimethyltryptamine, salvia divinorum and have a blast at Fillmore on the 4^th of July. Hell, that sounds like a great idea. Why haven’t I done that?

Maybe it’s because I’ve been too busy watching everything around me slowly dying and being reborn, reshuffled, or reapplied to a different section of this quasi-universe. Mmm…another hit from my most favorite light bulb vaporizer, perhaps the most ghetto way to get as much out of yr cannabis for as long as possible. Stay high as possible. For as long as possible. Wait, was that what I was sent here for? Or just some strange side-trip on my bigger journey of life?

This is exactly what I was asking myself as I laid in a bug-ridden tent in a river bottom, stuck in a K-hole, smacked out of my mind, with cannabinoid receptors firing and misfiring, imploding and exploding at such a horrific rate of speed that there was light, and darkness…Day, night…Sleep? No, of course not. What is that? Aren’t we already asleep? We wake up from one dream to fall asleep into another. The dreamer is the dreamed.

The screams of sex washed over my ear drums as my two tripping partners went at it in the neighboring tent (there is a small community called bamboo/tent city). I couldn’t tell what was worse, their incessant bitching at each other all night over any and everything, or their incredibly over exaggerated cries & moans of pleasure & sexy what nots.

The ketamine was weird, almost too weird but I couldn’t separate myself from the weirdness and I can’t very well call myself too weird, so it passed. There were strange beasts lurking all about, horrible monsters made of pure darkness and shadow, with fire and vengeance in their bottomless, black holes of eyes. What could I do but retreat and wait until they were vanquished by the coming dawn?

And somehow I’m back at an Agent Orange show a few years ago…Halloween, with the “Misfits”….

Bloodstains, speed kills,

Fast cars, cheap thrills,

Rich girls, fine wine

I’ve lost sense – I’ve lost control – I’ve lost my

Mind

Maybe that’s what I should have done. Started singing old punk songs and moshing with the fuckers. Why not? Beasts from the netherworld know how to really jam.

Death…That’s why. Or maybe life is why. Death, death, death…I know you well, friend. Just in the last week or so you’ve paid a visit to two of my friends…subjects the rest of my friends happened to be dwelling on. I never, ever know what to say to people who take the matter of death harshly. How can you get all whiney and crying & what not when you know that yr own death is right around the corner? If it’s even that far off…

And what is it that we lose, anyway? Who is there to die?

Well, I suppose there are two people that were there now that aren’t here anymore – whatever that means. One was stabbed to death over some petty pseudo-gang bullshit, the other overdosed shooting heroin and was pushed into his father’s front lawn, stone dead. I know a spell, and it goes N-A-R-C-A-N. Oh well, what can one do against death?

Not that the people I was with ever asked those kinds of questions. Sure, they ask the proverbial stoner questions, “Dude, do you think that anything is like, even real?” – but I have never seen one try to apply it to their life. “Well, my suffering isn’t real so there’s no reason to complain, is there?”

Dumbness, dumbness all around me and not a single way to move. Trapped, like a horrible, beady eye rat in a cage. Or maggots, burrowing into yr skin…eating yr flesh.

But hell, what can I do? I’m an idiot, too.

I’m just weirder.

More to come once I figure out where I hid everything.

Rizzo out.