Issue One

[OLD INTRO from Febu­rary 16th 2010]

Right, so roughly 9 months ago I came up with an idea for a drug mag­a­zine to cover stuff that recre­ational drug (ab)users would find help­ful, infor­ma­tive, and enter­tain­ing. There are plenty of weed mag­a­zines, but not much that cov­ers other sub­jects; at first I thought there were zero zines or pub­li­ca­tions like this but there are a few, includ­ing one done by Erowid. It was only a pass­ing idea that I came up with while in rehab and posted on the forums of Chempho­ria, not think­ing much of it. Peo­ple took to it, and so we set it up some arti­cle ideas, got some peo­ple work­ing on it, and came up with some cool ideas, art, arti­cles, etc.

There were many delays due to every god-awful rea­son in the book, but at the final stages of pro­duc­tion (i.e.; putting it into an actual zine form using soft­ware, which no one knew how to use) it was basi­cally aban­doned due to inter-forum/IRC chan­nel pol­i­tics. I won’t bore you with the details, but I basi­cally up and left and have all the files, infor­ma­tion, emails, etc that’s needed to con­tinue it. I’ve always rea­soned to myself that there’s no need to pro­tect against pla­gia­rism since no one could ever fol­low through; no one could ever write a sequel to some­thing I started.

And so we get to the point: I am in pos­ses­sion of sev­eral arti­cles and var­i­ous pieces of art work that could make a very awe­some first issue of a zine, but I am not going to put it into zine form. At least, not yet; it’s too involved and I have too lit­tle sup­port. How­ever I still feel the authors deserve some credit, and need­less to say cer­tain arti­cles are fairly rel­e­vant enough that they’re get­ting posted any­way (see: NoWarning’s opi­ate poten­ti­a­tion guide). I was going to try to put them into some sort of wiki for­mat, but that was a total clusterfuck.

Fail­ing every­thing else, I’m just going to post them here, and declar­ing that Dose is still mine. Spe­cific authors, if they want to say, “I don’t want you to use my arti­cle” are fine to tell me to take it down; I doubt how­ever that any­one cares about such petty inter­net politics.

Enjoy.

 

Eat the mana and know the divine

The Com­plete Idiot’s Guide To Get­ting a Bunch of Weird

Mon­sters to Wait in Empty Rooms

& Do Your Bidding

Pro­pri­etor: The Hap­pi­est Lit­tle Nug

 

The opening story sequence from A Link to the ...
Image via Wikipedia

 

There are many things that we, as humans, would like to accom­plish in life. Get­ting high, find­ing love, dis­cov­er­ing the secrets of the uni­verse, all fine and upstand­ing goals, but when it gets down to it what do we all really want? What do we all crave? Smack? No good sir, the answer…well the answer was power, and few things in this life com­mand more power and clair­voy­ance than get­ting a bunch of weird mon­sters to wait in empty rooms and do your bid­ding. Why you might ask? Well, what if some­one was to come along look­ing for you? Tell them to fuck off? No, this is much too arro­gant of a task. Instead leave mon­sters loyal to you and only you in every room you might be in or ever want to be in. Here’s where we get to the meat of this arti­cle, how exactly do you go about mind con­trol? Well all sorts of drug con­coc­tions have been tried by just about every­one to con­trol pop­u­la­tions of humans, ani­mals, any­thing bar­ley alive really, but only one really stands out. Scopo­lamine, the infa­mous tropane alka­loid from the Datura fam­ily, is that drug. Sub­jects under the effects of this drug have been know to:

  1. Fol­low every com­mand to the T no mat­ter how ridiculous.
  2. (See A.)
  3. (See Saw)

Any­way a fairly sim­ple process can be fol­lowed to do a home extrac­tion. Well what are you wait­ing for? The secret of mind con­trol is con­tained in the rest of this arti­cle! Aren’t you excited?…..not even a lit­tle? You will need: At least 10g of dried, ground datura plant mate­r­ial, NH4OHH2SO4, petro­leum ether and diethyl etherNA2SO4, dis­tilled water, and what­ever lab equip­ment you deem necessary.

Wet your 10 grams of datura with 15 ml of NH4OH. Then add 300ml of ethyl acetate and let it sit at room tem­per­a­ture for 72 hours. Fil­ter the extract and evap­o­rate your sol­vent. Dis­solve the residue in dis­tilled water and acid­ify with H2SO4 to around 3–4 PH. Then extract with petro­leum ether and diethyl ether to remove lipophilic, acidic and neu­tral mate­r­ial. After basi­fy­ing the solu­tion to PH 9–10 with your NH4OH, extract with chlo­ro­form and wash with dis­tilled water and dry with NA2SO4.

Now that you’ve done all that I’ll tell you how to iden­tify a com­mon datura plant that grows world wide. Odd that I tell you this after the extrac­tion I know, but I’m assum­ing if your seri­ous about being an idiot you’ll have read this at least once before try­ing it. What you’re look­ing for is know as Datura stra­mo­nium it grows like a woody, leafy bush and it smells nutty. Its leaves are soft, irreg­u­larly undu­late, and toothed. The flow­ers are trumpet-shaped, white to creamy or vio­let, and 2 to 3 inches long. The egg-shaped seed cap­sule is usu­ally cov­ered with spines. Or if you pre­fer grow­ing your own seeds are avail­able from many online ethno botan­i­cal sources. Bouncingbearbotanicals.com and ktbotanicals.com to name a few.

Datura stramonium 1 (2005 07 07)
Image via Wikipedia

Feel up for some his­tory? Datura was used med­i­c­i­nally by the Zuni, Aztec, and Mayan peo­ples. It was used to treat many ali­ments such as bruises, minor wounds, skin ulcers, hem­or­rhoids, Arthri­tis, rheuma­tism, and gen­eral swelling. Scopo­lamine hap­pens to be an excel­lent bronchial dila­tor mean­ing it can alle­vi­ate asth­matic symp­toms and other pul­monary con­di­tions, Recre­ational datura usage is known to have occurred since 2500 B.C [olmec shamans]. The herb is used today in many man­hood and div­ina­tion rit­u­als in Africa, India and China. The drug is also used med­ically today under the name Trans­derm and Sco­pace. They are used to relieve nau­sea, vom­it­ing, and dizzi­ness asso­ci­ated with motion sick­ness and recov­ery from anes­the­sia and surgery. Scopo­lamine may also be used in the treat­ment of parkin­son­ism, spas­tic mus­cle states, irri­ta­ble bowel syn­drome, diver­ti­c­uli­tis, and a whole mess of other things, but I think you get the picture.

Don’t become a sta­tis­tic. Don’t use scopo­lamine if you have or sus­pect hav­ing kid­ney dis­ease, liver dis­ease, an enlarged prostate, dif­fi­culty uri­nat­ing, a stom­ach obstruc­tion, heart dis­ease, blad­der prob­lems, or glau­coma. DO NOT EYEBALL DOSES, DO NOT DRIVE, DO NOT GO TO WORK, DO NOT ROB/RAPE/KILL ANYONE(at least, no rob­bing or rap­ing or killing with­out a doctor’s prescription).

 

 

 

 

Hail Discordia, Praise Robert Anton Wilson

 

 

 

Holy Fuck It’s a Coma, Get in the Bed!

OR:

What not to do with a bot­tle of cough syrup

Deliv­ered in Morse code by JoePedo

A short time ago, an indi­vid­ual wrote to us with the fol­low­ing account of a curi­ous experience:

Okay, so about 6 months ago, I almost died, and I’ve always won­dered what hap­pened, what chem­i­cal com­bi­na­tion caused it.I was in a field drink­ing Sparks (caf­feinated beer) with a good friend. I had drank about a bot­tle and a half of Del­sym around 12 hours ear­lier. So I only drank like 2 Sparks (and at this point i was a heavy drinker), and then I blacked out. From what I heard, I was sort of in a coma, I pissed myself, my nose was bleed­ing, i was mum­bling real bad and I couldn’t fuck­ing walk at all.

- “Skitzy,” via an inter­net mes­sage forum.

Shortly there­after, an indi­vid­ual going by the name of “Ford Pre­fect,” a community-respected chemist, noted the fol­low­ing observation:

Quote:

415 ml of dex­tromethor­phan poli­s­tirex would be about equal to 2500 mg of DXM HBr.

Yet, at the end of this exchange, no one in the dis­cus­sion was yet aware why such a low vol­ume of ethanol would pre­cip­i­tate a total coma. Regret­tably, a short time later, a mod­er­a­tor shut down the dis­cus­sion, mis­tak­ing it for a dis­cus­sion of single-receptor antag­o­nists rather than a com­plex dis­cus­sion of mol­e­c­u­lar neurobiology.

 

2D structure of anti-tussive drug dextromethor...
DXM

 

So WTF hap­pened, d0nnar?

On its low­est pos­si­ble stages, neu­ro­science is a very fas­ci­nat­ing thing. Some of our read­ers may have a back­ground in elec­tronic logic pro­cess­ing on a hard­ware level, and essen­tially, neu­ro­bi­ol­ogy func­tions in essen­tially the same way. Vir­tu­ally every indi­vid­ual neu­ron can be con­sid­ered to have an ‘upstream,’ and a ‘down­stream.’ Sim­i­larly to tran­sis­tor logic cir­cuits, each upstream input, or down­stream pro­jec­tion, can have an exci­ta­tory, or inhibitory, influ­ence on its own down­stream sec­ondary trans­mis­sion – sim­i­lar to the func­tions of such com­po­nents as AND &  NOT gates in tran­sis­tor logic.

Of course, any study of mol­e­c­u­lar neu­ro­bi­ol­ogy or mono­cel­lu­lar elec­tro­chem­i­cal neu­rol­ogy would be incom­plete with­out a study of neu­roanatomy. In this paper, we put for­ward the hypoth­e­sis that the woe­ful tale of “Skitzy” is not one of dex­tromethor­phan, but one of nora­dren­er­gic ener­va­tion of the entire CNS mass.

Don’t Eat the Blue Microdot / the Blue Microdot is my Friend!

Nora­dren­er­gic neu­ro­trans­mis­sion in the CNS, much like 5-HT neu­ro­trans­mis­sion, is an organ-centralized affair which ener­vates the entirety of the remain­ing CNS from a cen­tral body of con­trol. In humans and the major­ity of things whose cen­tral ner­vous sys­tems are even dis­tantly related to them, that cen­ter of con­trol of nora­dren­er­gic trans­mis­sion is known as the locus ceruleus

Some of you may be famil­iar with the term “locus” from such terms as “genius loci” or “locus of con­trol,” while the more met­ro­sex­ual among the read­er­ship [we have those? –ed], with their back­ground in inte­rior dec­o­rat­ing, will almost cer­tainly rec­og­nize “cerulean” imme­di­ately. That’s right, dear reader – an entire dis­ci­pline of sci­ence named an entire organ of the brain “the blue spot,” and one of the great joys of study in the sci­ences is learn­ing a lit­tle Greek and Latin and dis­cov­er­ing just how slightly cracked and loopy your coun­ter­parts and pre­de­ces­sors are. Since we live in an essen­tially pre­lit­er­ate soci­ety, no one reads this stuff, and so sci­ence con­tin­ues in a cul­ture which might best be euphem­ized as “unsu­per­vised,” in which some­one has an eight year old boy who is close to them arbi­trar­ily name their ran­dom num­ber, calls the fun­da­men­tal par­ti­cles of the uni­verse by a non­sense syl­la­ble in a poem from a work which most resem­bles one of Dodgson’s love-sonnets in the seri­ous­ness of its tone, and start refer­ring to such seri­ous and weighty mat­ters of the brain as “the blue spot” and “the black stripe” when they think no one speaks Latin. Charm­ing fel­lows, really, the sort of folks you love to take to par­ties in the hopes of get­ting them drunk and all.

But, for the moment, the main things one might need to know about the Locus ceruleus, this strange blue place, is that it con­trols nora­dren­er­gic trans­mis­sion, and that it has out­go­ing pro­jec­tions to essen­tially every other part of the brain – it’s down­right famous for its long neural pro­jec­tions, in fact. As for the locus ceruleans’ nora­dren­a­line itself, we note that hypocretin-signalled neu­ro­trans­mis­sion relies heav­ily on nora­dren­a­line for ini­ti­a­tion (see Grivel, 2005), and that sub­suf­fi­cient hypocretin/orexin trans­mis­sion is heav­ily impli­cated in abject nar­colepsy (Mignot, 2000).

NORLY, WTF hap­pened, d0nnar??

Remem­ber above, where the basic struc­ture of neu­ro­trans­mis­sion – upstream and down­stream release in the cas­cade induc­ing inhibitory and exci­ta­tory effects – was elucidated?

Well, we pro­pose that what hap­pened was very sim­ple. GABA is already known to be cen­tral to inhibitory gat­ing of the locus ceruleans (see Ennis, 1989, for more info), while NMDA glu­tamer­gic neu­rons are entirely charged with the hyporexin-mediated exci­a­tory effects which nora­dren­a­line holds on con­scious­ness – those inter­ested in fur­ther read­ing may wish to review the appropriately-titled “Exci­ta­tory Effects of Hypocretin-1 (Orexin-A) in the Trigem­i­nal Motor Nucleus Are Reversed by NMDA Antag­o­nism,” whose title is sug­ges­tively rem­i­nis­cent of “Schitzy’s” claims.

In short, we pro­pose that the indi­vid­ual known as “Schitzy” uti­lized 2.5 grams of the n-methyldextroaspartate-sensitive glu­tamer­gic recep­tor antag­o­nist dex­tromethor­phan, along with the intro­duc­tion of the broad-spectrum GABA ago­nist ethanol, specif­i­cally and sur­gi­cally induced the total sep­a­ra­tion of the consciousness-excitatory path­ways of the locus ceruleans from their neural tis­sue via the absolute inhi­bi­tion of all upstream and down­stream path­ways, result­ing in imme­di­ate and total coma.

Con­clu­sion

We believe the case of “Schitzy” illus­trates a need among the com­mu­nity of con­sump­tion of bioac­tive mol­e­cules for a greater degree of edu­ca­tion in human phys­i­ol­ogy, specif­i­cally includ­ing mol­e­c­u­lar neu­rol­ogy, neu­roanatomy, and famil­iar­ity with the cytochrome p450 sys­tems. No respon­si­ble researcher would advo­cate the com­plete and total exci­sion of an entire organ’s con­tact with sur­round­ing brain tis­sue in a healthy human being, and even of the most pass­ing of famil­iar­i­ties with the effects of these drugs on con­scious­ness acti­va­tion sys­tems would have had some chance to have pre­dicted the poten­tial exci­sion and dis­in­te­gra­tion of neural sig­nal­ing, to the point where ethanol-induced loss of con­scious­ness and Ca++-mediated neu­ro­tox­i­c­ity in amphet­a­mine use are openly dis­cussed in their respec­tive lay com­mu­ni­ties. We believe the bur­den of edu­ca­tion and knowl­edge regard­ing the actions of neu­roac­tive com­pounds lies with any­one seek­ing to con­sume them, rather than with police, par­ents, man­u­fac­tur­ers, or worst of all, a gov­ern­ment which has already woe­fully failed in total drug edu­ca­tion mis­in­for­ma­tion, and con­sider the cul­ti­va­tion of a sense of neu­rore­spon­si­bil­ity among the com­mu­nity to be the lead­ing health issue of impor­tance for our soci­ety. Bioac­tiv­ity is no respecter of lines of legal­ity or ille­gal­i­ties – both cin­na­mon and sage syn­er­gize in their actions to lower the seizure thresh­old, for instance, in path­ways sim­i­lar to the ones noted here – and a sense of knowl­edge as the duty of the respon­si­bil­ity which is a pre­req­ui­site of con­sump­tion is of vital impor­tance to cul­ti­vate for our age.

 

 

 

I have no idea who this picture belongs to.

 

 

 

NoWarning’s New & Improved Opi­ate Poten­ti­a­tion Guide

The scene: a twenty year old junkie rushes back to his hell-hole of his apart­ment, buzzing with anx­i­ety to get his fix. Con­tra­band in hand, he opens his door, and even as he makes con­tact with the door­knob he knows. “Fuck…I’m short. This isn’t going to get me high”

…He rushes in, pre­pares his shot, hits his favorite vein, sinks to the floor as the rush hits him. Five min­utes later, our junkie is rag­ing, fum­ing – a ver­i­ta­ble wild-fire of opiod rage. Slowly, he sinks to the floor, won­der­ing what to do, in fact, what is there to do? That is, besides…

Opiod Poten­ti­a­tion

Now that we’ve set the scene and have got some opium-based-alkaloid drama going. Fol­low this for­mula and rest assured, you will be hypo­thet­i­cally nod­ding, but of course you won’t since no one does drugs if they aren’t pre­scribed to you by a qual­i­fied physi­cian. Right? Good.

But before the cli­matic new edi­tion of N0 W4RN1NG’s “patented” opiod poten­ti­at­ing recipe, first let’s engage in a bit of fore­play. Expla­na­tion time, divided into classes:

Anti­his­t­a­mines

Anti­his­t­a­mines are com­mon drugs that have been well-known to enhance the effects of opi­ods. By def­i­n­i­tion, an anti­his­t­a­mine is any drug that inhibits the release of, or the actions of his­t­a­mine. They tend to increase seda­tion in most and eupho­ria in some, and have the added ben­e­fit of reduc­ing itch­ing. This is because his­t­a­mines are released as a response to aller­gens and other itch-causing sources. There is, how­ever, some debate over which type of his­t­a­mine is supe­rior for com­bat­ing itch. H1 recep­tor antag­o­nists (clas­sic anti­his­t­a­mines) are gen­er­ally believed to be the best for com­bat­ing itch and induc­ing seda­tion – our cur­rent goal. H2 recep­tor antag­o­nists are thought to have, at most, a slight effect on both itch & seda­tion, whereas H3 actu­ally has an oppo­site effect. Appar­ently, the supe­ri­or­ity of H1 recep­tor antag­o­nists lies in its mech­a­nism of action, which was stud­ied over a decade ago:

“These effects of neu­ronal his­t­a­mine upon cor­ti­cal neu­rons are likely to affect synap­tic trans­mis­sion in sev­eral ways. The depo­lar­iza­tion per se should increase the like­li­hood that exci­ta­tory synap­tic poten­tials will evoke an action poten­tial. The increase in whole-cell input resis­tance evoked by H1 recep­tor acti­va­tion should make the cell more elec­tro­ton­i­cally com­pact, thereby alter­ing its inte­gra­tive prop­er­ties. We hypoth­e­size that these mech­a­nisms would allow his­t­a­mine, act­ing at cor­ti­cal H1 recep­tors, to enhance behav­ioral arousal. Dur­ing wak­ing when his­t­a­mine release is high­est, block­ade of H1 recep­tors by sys­tem­i­cally admin­is­tered H1 recep­tor antag­o­nists would be sedating.”

- Reiner PB, Kamondi A, “Mech­a­nisms of antihistamine-induced seda­tion in the human brain: H1 recep­tor acti­va­tion reduces a back­ground leak­age potas­sium cur­rent.” Neu­ro­science. 1994 Apr;59(3):579–88.

In the realm of per­sonal expe­ri­ence, I would have to say that, as a gen­eral prin­ci­ple, the ethanolamine class of anti­his­t­a­mines is the most effec­tive at boost­ing the desired effects. Par­tic­u­larly, phenyl­tolox­am­ine is my per­sonal favorite of the over-the-counter anti­his­t­a­mines. You won’t find it a soli­tary drug – it only appears in com­bi­na­tion for­mu­la­tions with aspirin or other sal­i­cy­lates (or aceta­minophen), but a dose of 60–90 mgs of phenyl­tolox­am­ine is a solid way to boost any opi­ate expe­ri­ence. Unlike other anti­his­t­a­mines (CPM), it doesn’t dom­i­nate the opi­ate high as much.

Other promi­nent anti­his­t­a­mines include the clas­sic diphen­hy­dramine (at a dose of 25–50 mgs) and DPH’s mother, dimen­hy­dri­nate. As a slight digres­sion, dimen­hy­dri­nate is cleaved into the caf­feine rel­a­tive, theo­phylline, so it in the­ory might be more use­ful than diphen­hy­dramine alone – this could coun­ter­act the drowsi­ness to some extent. Besides those pre­scrip­tion anti­his­t­a­mines, doxy­lamine and ele­mas­tine are the other options, how­ever they’re noth­ing special.

As far as the pre­scrip­tion anti­his­t­a­mines go, ophenadrine is (in my opin­ion) the best, although it is not that much bet­ter than OTC phenyl­tolox­am­ine – it does seem to be a good bet, though. Com­ing in a close sec­ond and third place, hydrox­yzine and promet­hazine are damn good non-enthanolamine pre­scrip­tion anti­his­t­a­mines. On a related note, the piperzine Meclizine is over-the-counter and very use­ful at com­bat­ing nau­sea (cannabis will always be the best at this, though). It’s a good drug to take if you’re not sure of your tol­er­ance and are prone to opiate-induced pro­jec­tile vom­it­ing. Bleeeech­h­hhh. Lunch, all over the walls. No one wants this…

The other com­monly found anti­his­t­a­mines are chlor­pheni­ramine (CCC) and Brompheni­ramine (Dimetapp). I have per­son­ally come to dis­like chlor­pheni­ramine, but if it’s all you have than it is bet­ter than noth­ing. Do your­self a favor, though, and cap your max dose at 4 mgs. Brompheni­ramine is nice, but not nearly as effec­tive as the ethanolamine staples.

 

Dex­tromethor­phan (DXM)

 

Sigma ago­nist, NMDA antag­o­nist, nico­tinic recep­tor antag­o­nist, sero­tonin releaser, dis­so­cia­tive anes­thetic, tol­er­ance reducer, and high poten­ti­a­tior – dex­tromethor­phan is all that and prob­a­bly more. Brain chem­istry is com­pli­cated, to say the least. DXM is how­ever, also the eas­i­est way to turn a smooth and clean oxy­codone buzz and drench it in dirty weird­ness. I usu­ally rec­om­mend only tak­ing 30 mgs of DXM, and would def­i­nitely cap the dose at 60 mgs. At 30 mgs the effect is barely notice­able, but at dou­ble the dose one might begin to feel slightly dif­fer­ent, detached.  A small warn­ing: DXM does syn­er­gis­ti­cally depress res­pi­ra­tory func­tions when used along with opi­ods. Tak­ing 60 mgs with an already strong dose can be a bit dan­ger­ous, although it isn’t very likely.

 

Antacids

 

Hav­ing a basic(high) pH in your stom­ach has been shown to enhance opiod bioavail­abil­ity when con­sumed orally, as well as the rate of absorp­tion. Tak­ing a tums or two, bak­ing soda or even mag­ne­sium oxide/hydroxide an hour or so before you ingest your opi­ate of choice will have pos­si­bly dra­matic effects on your expe­ri­ence, depend­ing on the usual pH of your stom­ach. And, speak­ing of magnesium…

 

Mag­ne­sium

 

While mag­ne­sium oxide is a great agent for basi­fy­ing the stom­ach, but as a sole source of mag­ne­sium, it’s fairly – excuse the tech­ni­cal jar­gon – shitty. Tak­ing approx­i­mately 400–600 mgs of mag­ne­sium cit­rate, tau­rate, gly­ci­nate, or as a chelate will enhance the expe­ri­ence. Like DXM, mag­ne­sium is an NMDA antag­o­nist, which can mean many things, but in this case it means that it can aid in pre­vent­ing the build up of the much dreaded opi­ate tol­er­ance. Also, high doses of mag­ne­sium can have a mild sedat­ing effect, which of course blends in nicely with any opi­ate buzz. Expectt mild lax­a­tive effects, as well.

 

Cariso­prodol (soma)

 

For what­ever rea­son, Soma, (and its active metabo­lite, meproba­mate) are extremely use­ful in enhanc­ing the opi­ate expe­ri­ence. A dose even as low as 200 mg of meproba­mate or 350 mg of cariso­prodol will have a very pos­i­tive effect on your high. Take them at the same time if you are eat­ing your opi­ate, or twenty min­utes before hand if you’re rail­ing it or shoot­ing it. They have a pretty long half life, but the sought-after-effects seems to only last four hours, max. They are Rx only, and meproba­mate is rarely pre­scribed these days – but Soma is easy to find on the streets and the inter­net of course con­tains any­thing and every­thing. If you know where to look…

 

Dopamine Pre­cur­sors

 

The amino acids pheny­lala­nine and tyro­sine are nec­es­sary to cre­ate dopamine in the brain. One of the won­der­ful effects of opi­ates is that they indi­rectly raise dopamine lev­els in the brain. That means that, the­o­ret­i­cally, hav­ing some of dopamine’s direct pre­cur­sors abun­dant in your brain will lead to increased plasma con­cen­tra­tions of dopamine in the pres­ence of a dopamin­er­genic drug.

DL-phenylalaline at a dose of 1000 mg seems to really ramp up the energy and eupho­ria when taken at 500 mg, 30 min­utes before inges­tion) and then another 500 mgs ten to fif­teen min­utes later. Also, 250–500 mg of n-acetyl-tyrosine has sim­i­lar effects.

I’ve found that, sim­i­lar to how MDMA con­nois­seurs will pre­load with 5-HTP or l-tryptophan, notice­able effects can be achieved with opi­ates by pre­load­ing for a day or two before­hand with DLPA. Tyro­sine should work as well, although I have no per­sonal expe­ri­ence with it.

 

Caf­feine

 

In addi­tion to off­set­ting drowsi­ness, a mod­est dose of caf­feine will prep the brain for opti­mum dopamine pro­duc­tion. This is espe­cially impor­tant if you took dopamine pre­cur­sors, and as such tak­ing energy drinks full of strange herbs is advised against [who knows what inter­ac­tions are pos­si­ble — maybe impo­tency, or chem­i­cal lobot­o­mies – ED]. A cup of cof­fee or tea should do the trick. Now on to the real fun stuff…

 

Enzyme Inhi­bi­tion & Manipulation:

 

Before div­ing in, some basic primers on the sub­ject: codeine and codeinones (hydrocodone, oxy­codone, etc) are gen­er­ally han­dled by two main cytochrome P450 enzymes: CYP3A4 and SYP2D6 (as well as glu­coro­nida­tion). CYP3A4 processes your fun lit­tle friends into bor­ing geeks like (mostly) inac­tive nor­codeine. CYP2D6 metab­o­lizes the goods into some really wild stuff like hydro­mor­phone, oxy­mor­phone, and such. So with codeine related drugs, you’re going to want to “clog” up the enzyme CYP3A4 to ensure that as much oxy­codone or what have you is A) not processed into an active metabo­lite and B) come up on a lit­tle extra oxymorphone.

 

White Grape­fruit Juice (Concentrate)

 

Yes, the cheap stuff. Make sure it’s 100% juice and that all of said juice is white grape­fruit juice. A few stud­ies have shown there to be sig­nif­i­cantly higher lev­els of 6-hydroxy-bergamottin, the main CYP34A inhibitor in white grape­fruit, which is in the ghetto-cheap-concentrated juices as ver­sus the freshly squeezed kind. I’m cer­tainly not complaining…

Addi­tion­ally, white grape­fruit juice is, for what­ever counter-intuitive rea­son, actu­ally a base once inside your stom­ach. Which means it actu­ally raises pH once inside you, sim­i­lar to what a Tums would do. A tall glass or two of this stuff an hour before ingest­ing some opi­ates should suffice.

 

Taga­met

 

Taga­met HB (cime­ti­dine HCl) is an OTC broad range CYP450 inhibitor. It inhibits 3A4 and 2d6 fairly well, although not nearly as well on 3A4 as well as white grape­fruit does. This makes it ideal not only for oxy­codone and hydrocodone, but also mor­phine & its rel­a­tives. Miss mor­phine and her broth­ers and sis­ters heroin, hydro­mor­phone, etc, get con­verted into inac­tives by 2D6 and also by a process known as glu­curonida­tion. Taga­met and white grape­fruit juice work very well with oxy­codone and hydrocodone, together they pro­long the high and inten­sify the peak. With heroin and hydro­mor­phone, white grape­fruit juice doesn’t seem to effect it much at all, and taga­met has an effect sim­i­lar to but lack­ing in the inten­sity as with hydro or oxy. The sweet spot in my expe­ri­ences has been 600 mg, an hour before dosing.

 

Qui­nine & Quinidine:

 

Qui­nine is the ingre­di­ent that gives tonic water that taste that’s so bit­ter and well, ton­ic­li­cious. Did I men­tion that fact that it’s a mild inhibitor of CYP2D6? A cou­ple of glasses of tonic water an hour or so before your heroin/morphine/hydromorphone will lengthen the buzz, espe­cially com­bined with taga­met. Because tonic water is acidic, if you plan on eat­ing your morphine/heroin/hydromoprhone (which is stu­pid – the oral bioavail­abil­ity on all of those blows), you need to take Tums with your drink to coun­ter­act the acidity.

 

Well­butrin (bupropion)

 

Well­butrin is, in this writer’s opin­ion, one of the best fuck­ing mor­phine poten­tia­tors out there. It is an extremely strong CYP2D6 inhibitor , and it also has some mild dopamine reup­take inhibitor and stim­u­lant prop­er­ties of its own. Approx­i­mately 100 mg taken orally [fun note: peo­ple have reported cocaine-like rushes when inject­ing bupro­pion – more on that next issue! – ed] before your mor­phine or mor­phone will sig­nif­i­cantly lengthen the effects as well as adding a bit of stim­u­la­tion and extra eupho­ria to the experience.

 

Glu­coro­nida­tion

 

Here we have some­thing brand new, as far as I know no one has yet attempted to inhibit glu­coro­nida­tion in an effort to enhance opi­ate effects. I’ve thrown around CYP450 inhi­bi­tion for a while now, but it always both­ered me that whil eef­fects are def­i­nitely present, they are not as strong as they the­o­ret­i­cally should be if you were really clog­ging all exit paths for the opi­ate. Then I real­ized that a good por­tion of most opi­oids (espe­cially mor­phine) is han­dled by a sep­a­rate set of enzymes, enzymes that con­ju­gate opi­ates to an inac­tive glu­coro­nic acid salt. I didn’t know much about these at the time, so I lost inter­est and for­got about them; recently, how­ever, I stum­bled upon the con­cept of glu­coro­nida­tion inhibitors – the­o­ret­i­cally, in com­bi­na­tion with CYP450 inhibitors, glu­coro­nida­tion inhibitors would pro­vide extreme length­en­ing of the opi­ate high.

And yes, they do exist.

Opi­ods like oxy­codone are pri­mar­ily glu­coro­nized through a fun lit­tle guy called UGT2B7, unfor­tu­nately there are not too many OTC inhibitors of our friend. Or at least, that I’ve found  [sub­mit any­thing you find to dosezine@gmail.com if you please – ed] – though the two that I found are laugh­ably enough qui­nine and naproxen. Appar­ently, super human dosages of naprox­one and qui­nine would be nec­es­sary to pre­cip­i­tate a notice­able effect on UGT2B7 inhi­bi­tion. The inhi­bi­tion would be syn­er­gis­tic so both should be used at once. Based on pre­lim­i­nary research, you would have to drink some­thing like a bot­tle of tonic water along with roughly 800 mg of Aleve. This amount of naproxen is some­times pre­scribed for acute pain man­age­ment, but may not be safe for every­one. Do not drink alco­hol with this combo and avoid APAP (aceta­minophen) out of prin­ci­ple.
That said, to get the ABSOLUTE MOST out of your opi­ate, try N0 W4RN1NG’s (brand fuckin’ new) patented opi­oid poten­ti­a­tion formula:

* T-60) 600mg Taga­met HB(Cimetidine HCl), 1000mg DLPA OR 500mg N-Acetyl-Tyrosine and a large glass of (white) Grape­fruit juice, prefer­ably from con­cen­trate. Add in an extra strength tums or 1.5tbsp. of bak­ing soda if you are going to be eat­ing your opi­ates.
* T-45) 30mg DXM HBr, 90mg phenyl­to­lax­am­ine cit­rate, 600mg Mag­ne­sium citrate\taurate\glycinate\chelate
* T-20 A bot­tle of tonic water (qui­nine), 880mg Naproxen Sodium. A cup of cof­fee, or a strong black tea. Take another tums now if you’re eat­ing your opi­ate to coun­ter­act the tonic water
* T-0) Parachute\chew\rail\bang your opi­ate
* T+10) Smoke a bowl or two. Not more, you don’t want to over power it.

 

 

DMT Primer

Revealed to Scovenger by hyper-elves in the 9th dimension

 

Note that Scovenger has only a passing resemblance to McKenna.

 

N,N-dimethyltryptamine (DMT) is a hal­lu­cino­gen found endoge­nously in human brain that is com­monly rec­og­nized to tar­get the 5-hydroxytryptamine 2A recep­tor or the trace amine–associated recep­tor to exert its psy­che­delic effect.

It’s found in many plants, but the main source of it for recre­ational use is the plant mimosa hos­tilis, an ever­green shrub that nat­u­rally grows in Brazil, but can be mail-ordered from many places. Cau­tion must be exer­cised with it though; used prop­erly it can be one of the strongest psy­che­delics, actu­ally no scratch that, pure con­nec­tion to the spir­i­tual under­world of energy, and this energy must be respected and flow in the right directions.

 

Extrac­tion:

There is a com­mon method that you can find named the ‘lazy mans tek’,  it’s very sim­ple to do you just need ground mimosa, water, lye and naptha, all pretty eas­ily avail­able. All I would add to this is that instead of evap­o­rat­ing, use a small vol­ume of sol­vent (approx­i­mately 20ml/100g mimosa), and once you have sep­a­rated it, put it into the freezer at as low a tem­per­a­ture as it will go, and leave overnight. In the morn­ing you should have some beau­ti­ful crys­tals stick­ing to the sides of your con­tainer. This works by the prin­ci­ple of freeze pre­cip­i­ta­tion; the sol­u­bil­ity of DMT in your naph­tha drops rapidly as it gets cold. Mov­ing quickly to avoid it dis­solv­ing again as it heats up, pour the naph­tha through a metal cof­fee fil­ter to catch any spare crys­tals that have fallen off, and air dry your crys­tals to avoid any traces of naph­tha. Believe me, smok­ing naph­tha is NOT any fun. Scrape them up and col­lect, store them in a freezer to avoid them degrad­ing in heat and light.

 

 

DMT crystal at 400x magnification
Image via Wikipedia

Expe­ri­ence:

Let me start with say­ing; noth­ing will really pre­pare you for it, but if you edu­cate your­self on it as much as you can then there’s not much risk. The essen­tial part of it really is to just ‘go with the flow’, no mat­ter how stereo­typ­i­cal it sounds it is true. Before the trip it’s pretty usual to be pretty anx­ious, I always make sure I’m clean, in a good tem­per­a­ture room, not too hot or too cold, take a piss
before­hand just in case you get scared  .. some quiet sooth­ing music can be good, but other times it can just be very irritating.

Light­ing doesn’t mat­ter a huge amount, just make sure it isn’t too harsh light, and bright sun­light can also be irri­tat­ing to the eyes some­times. Take a few deep breaths, relax, and inhale deeply. Hold it in for as long as you can, then gen­tly exhale. At this point you’ll feel it com­ing on strongly. Usu­ally the anx­i­ety dis­ap­pears soon after, and you go into it. It WILL be pow­er­ful, totally unlike any­thing you’ve ever seen before. From there on you should be able to take care of your­self inside your mind. Try and keep your eyes closed as it leads to much more vivid visions, but open eyes can work ok as well.

In some ways it’s good to start with a low dose to get your­self used to the feel­ing, but oth­ers may just want to plunge straight in to be totally awed by it. If you do man­age to see elves, or enti­ties, RESPECT THEM. One last thing, you may get the feel­ing you’ve shat/pissed your­self, don’t worry, you’ve not, just ignore it.

Many com­plain about the taste but TBH as long as your DMT is pretty clean, it isn’t THAT bad, although very dry on the throat.
A bong will help immensely, smooooth and allow­ing you to take big hits, but fil­ters out a small amount of the active ingre­di­ents.
You want to get all of your dose in quickly, less than a minute/until you can’t take any more sort of thing. A typ­i­cal ‘base pipe’ also works very well, find one with a large cham­ber to take big hits quickly.

As for how to smoke it, I’ve found it can work pretty nice using an ordi­nary pipe or bong, with a bit of a brillo pad under­neath, and a metal screen on top. Hold the lighter about 1″ away from it, heat very gen­tly as it doesn’t take much heat, and inhale deeply. A vapor­iser will work much nicer, although harsher, get a base pipe and use that. Make sure not to use the same para­pher­na­lia for dmt and weed unless you want to be slightly trip­ping every time you get stoned, again believe me that is not nice.

 

San Albert Hofmann, por Alex Grey
Image by ddaa via Flickr

Don’t do it too often or it can mess with your head, and be in a calm atmos­phere where you’re sure nobody will dis­turb you.
Use a trip-sitter if you wish to, but they’re not 100% nec­es­sary. A nice woodland/lochside envi­ron­ment just after dawn on a sum­mers day would be per­fect IMHO.

Make absolutely sure you weigh it cor­rectly. 20mg will have you def­i­nitely feel­ing it, but will feel quite empty and won’t ‘go any­where’, around the 60mg mark is where you can prop­erly ‘break through’ out of real­ity and into your full-on expe­ri­ence, how­ever it won’t be nearly as vivid and real as if you took 100mg. Be aware of what should hap­pen, and scale up your doses slowly so you’re famil­iar with the mind­set it puts you in. Use a good dig­i­tal scale with a MINIMUM res­o­lu­tion of 0.01g, although a mil­ligram scale would
be def­i­nitely preferential.

Some make com­par­isons to other drugs such as salvia. In some ways they’re half-similar with their total unique­ness and length of dura­tion etc, but they’re TOTALLY dif­fer­ent tbh

DMT is EXTREMELY spir­i­tual, ener­getic and glow­ing, sacred, totally unde­scrib­able while salvia is just total mindfuck-drab coloured-dysphoric-alter real­ity sort of thing.

 

shr00ms

 

Bet­ter than Laugh­ing Gas

Writ­ten in a meth-frenzy by Killing

Xenon is a gas typ­i­cally used in “neon light­ing” and when excited by elec­tri­cal dis­charge, xenon emits a blue glow. As a result of its increased lumi­nos­ity and direct light flow, xenon is often pre­ferred in lux­ury car head­lights – as opposed to less exotic, halo­gen bulbs. Neon lights could be the source for this anes­thetic gas that closely resem­bles nitrous oxide, with some major differences.

When used as an anes­thetic, xenon is said to be an almost ideal agent; xenon is a col­or­less, odor­less gas that causes no irri­ta­tion to the user, and is also non-toxic and has proven to be hypoal­ler­genic. By hav­ing low blood-gas coef­fi­cients, which is the gaseous equiv­a­lent of sol­u­bil­ity, the effects of xenon are rather rapid. It can pro­duce uncon­scious­ness, anal­ge­sia (pain-kill), and mus­cle relax­ation. It does not cause any pro­found res­pi­ra­tory depres­sion, and is car­diac sta­ble. “Xenon anes­the­sia pro­duces the high­est regional blood flow in the brain, liver, kid­ney and intes­tine”  This means that the heart and brain are not put under any exces­sive strain.

Since it is a noble gas, and as such requires extreme con­di­tions to react with other ele­ments, it is not metab­o­lized in the body – it can be reused to achieve the ini­tial effect. The xenon one inhales is iden­ti­cal to the xenon which one exhales, and it is easy to store since it is sta­ble and non­flam­ma­ble. The only prob­lem with xenon is its pro­hib­i­tive price; it is very expen­sive and can only be used effi­ciently through a recy­cling system.

Recre­ation­ally, xenon has a lot of poten­tial. It is said to be one and a half times more potent as an anes­thetic than nitrous oxide (Crit­i­cal Care Med­ical Jour­nal). Trip reports speak of vocal dis­tor­tion, head rushes, and sim­i­lar actions to nitrous oxide. Recre­ational use has not been pio­neered to any great extent yet, despite xenon’s enor­mous poten­tial as a recre­ational drug. It owes much of that to its high cost and obscurity.

Dos­ing xenon accu­rately can be tricky, to say the least. A trip report on Lycaeum stated that the user took a 50:50 mix of xenon / oxy­gen, and anes­thetic sites state that a mix­ture of 70:30 pro­duces full anal­ge­sia with amne­si­atic effects. So going on a 50:50 mix would be wise for cal­cu­lat­ing doses. The aver­age lung capac­ity is 5L, so a dose of xenon, using the 50:50 dose, would be about 2.5L. While these dosage ratios are very impor­tant for long term expo­sure, xenon gas may be treated as nitrous oxide. A bal­loon full of xenon will more than cover it. Just make sure to also take a break every few min­utes, oxy­gen depri­va­tion is not a good thing. Since it is not metab­o­lized, the user can exhale back into the bal­loon and reuse it.

While xenon is avail­able online or through mail order from indus­trial gas sup­pli­ers, it is very cost pro­hib­i­tive. The small­est quan­tity avail­able is a 25L tank for $485.00. Larger, indus­trial sized tanks can bring the cost down to around $10/L, which is roughly half the price for lower quantities.

Since xenon is an inert gas, when exhaled it is unchanged. A recy­cler sys­tem can be made with a few cheap items. The body only metab­o­lizes 4–5% of the oxy­gen breathed. So you will exhale oxy­gen, car­bon diox­ide, and xenon (assum­ing you are using pure oxy­gen and xenon). Car­bon diox­ide is eas­ily fil­tered out using a CO2 scrub­ber. The basic prin­ci­ple of a CO2 scrub­ber is that CO2, when mixed with water, forms car­bonic acid, which can be neu­tral­ized by expos­ing it to a strong basic agent, like NaOH (lye) or KOH (caus­tic potash) and hydrated lime. Oxy­gen is eas­ily absorbed using an oxy­gen absorber, typ­i­cally found in food pack­ages. Just remem­ber, if they are exposed to the open air, they will only last around 20 min­utes because they are absorb­ing all the oxy­gen in the air.

Xenon may also actu­ally pos­sess a med­i­c­i­nal value. It has been shown to have neu­ro­pro­tec­tant qual­i­ties. This means that xenon can help block out any harm­ful chem­i­cals that can dam­age nerve cells. Xenon may help reduce “… ischemia-induced brain dam­age…” Ischemia induced brain dam­age is dam­age that occurs because of restricted blood flow. Amphet­a­mine & related chem­i­cals are vaso­con­stric­tors, thus block­ing blood flow, thus the con­nec­tion is made that xenon may help with (meth)amphetamine toxicity.

Addi­tion­ally, xenon has, “ben­e­fi­cial effects on ischemia-induced neu­ronal death and amphetamine-induced sen­si­ti­za­tion.” (http://www.ncbi.nlm.nih.gov/entrez/q…uids=16179534). Since the Xenon can reduce dam­age caused by lack of blood flow, any vaso­con­stric­tors neu­ro­tox­i­c­ity could be partly reduced by using xenon. Dam­age done by cocaine, MDMA, amphet­a­mine, and metham­phet­a­mine may all be much more con­trol­lable through the use of xenon…
 

Appar­ently

 

http://jasn.asnjournals.org/content/20/4/713.full

Any infor­ma­tion or expe­ri­ences you have with the only noble gas that will get you high? Send them to dosezine@gmail.com !

The Inject­ing Pills Safely Dance

Writ­ten by Killing using brain-waves

NOTE: Inject­ing pills is not rec­om­mended! Inject­ing any­thing non-medical is not rec­om­mended! How­ever, we know that it’s going to hap­pen. I do it myself. If you do inject pills please fol­low these guide­lines as a means of harm reduc­tion, although by no means take this as a guide to mak­ing your inject­ing expe­ri­ence “safe”. No mat­ter how you do it, recre­ational IV drug use never falls under “safe”.
I will first walk you though how to prep pills. I am bas­ing this guide off of my expe­ri­ence with pur­due oxy­con­tins, rox­i­codones, and dilau­dids. This guide will work for most other pills where the active ingre­di­ent is water sol­u­ble.
First get two spoons and wipe them down with iso­propanol (IPA) –w hile you are doing this, wipe your fin­gers down. Crush/grind the pill(s) in the spoon. Add water. I typ­i­cally add 1 and 1/2 as much water as I am plan­ning on shooting.

Now stir the solu­tion around – I usu­ally use the orange cap from the syringe after I’ve wiped it with IPA. Drop a cot­ton ball in the spoon and suck up into a syringe. If you have wheel micron fil­ters, use a slip tip syringe. Once you have the solu­tion on the syringe put the micron fil­ter on the end and hold the fil­ter. Empty the syringe into your sec­ond ster­il­ized spoon.
I like to do a wash on what remains in the first spoon. I add around 10 units of water and repeat the pre­vi­ous step, and now you have your solu­tion in your sec­ond spoon add a lit­tle heat until right before it starts bub­bling. I usu­ally suck this solu­tion up into a syringe with­out a cot­ton fil­ter, or if I did not use a micron fil­ter I use a smaller, tighter cot­ton filter.

Inject, and let the fun begin!
This method allows you to do a few things:
You fil­ter twice
Your first fil­ter is cold, which keeps out binders/fillers by play­ing with sol­u­bil­ity
You do get to heat to ster­il­ize your shot

Help­ful Tips:
Your body will like more dilute shots. Use lots of water.
While this is a pref­er­ence thing, Using 1cc syringes allows you to prep with a good amount of water. I rec­om­mend them.

Inject slowly! If your plunger is hard to move down, pull it out of your arm. You’ve most likely got a clogged nee­dle. You do not want to inject that.
Hav­ing a good tourni­quet is really help­ful. Elas­tic ones work bet­ter than some­thing with no stretch. Remem­ber to release before you start inject­ing your shot!
Always reg­is­ter! If you are read­ing this guide you prob­a­bly aren’t at the point where you can feel if you are in your vein or not! Inject­ing under your skin is not pretty.
If you feel any pain while inject­ing you are most likely out of the vein. Re-register to dou­ble check.
Always apply pres­sure to the injec­tion site after you inject. It helps your body heal and will dra­mat­i­cally reduce track marks and bruis­ing!
Be lib­eral with iso­propyl alco­hol. It is good to put on your hands, your equip­ment, and the injec­tion site. Just be sure it has evap­o­rated before you do any­thing!
MICRON FILTERS ARE HIGHLY RECOMMENDED!

Sent by Divine Mes­sen­ger at the whim of Rizzo

Rizzo’s Sixth Cir­cuit Psy­che­delic Cir­cus

The expe­ri­ence of human con­scious­ness has been accu­rately described to be divided into two groups of four lev­els. While this idea is cer­tainly noth­ing new,
as all mys­ti­cal & spir­i­tual ideas are being con­stantly rehashed and recy­cled as they come to us from the fur­thest reaches of space (both inner and outer) -
Dr. Leary brought it into a more main­stream light. How­ever, unlike some of his other ideas regard­ing con­scious­ness and the expan­sion or explo­ration thereof,
the 8-circuit model will most prob­a­bly not get you thrown into prison.

The sub­ject of it is vast, as vast as con­scious­ness itself. Dis­cussing the intri­ca­cies of all the cir­cuits would take vol­umes, espe­cially as you go higher and
higher up. In fact, one could argue rea­son­ably well that you could spend yr entire life try­ing to talk about the 8th cir­cuit, the quan­tum cir­cuit. Of course,
words will always fail one there. Which is why I have cho­sen one of the more mys­te­ri­ous, elu­sive, and –yet in my view, the absolute funnest cir­cuit around. –

That view is entirely sub­jec­tive of course, but I hope to share with you some of the delights of the sixth circuit.

Now, the con­cepts that I have regard­ing the 8-circuit model are not just par­rots of what Leary, Robert Anton Wil­son, Gur­di­j­eff, and all the gurus and
teach­ers have put forth. There are basic sim­i­lar­i­ties that every­one can agree on, but from per­sonal expe­ri­ence I have to dis­agree with cer­tain points. *This
will hap­pen to any­one that attempts to think orig­i­nally and creatively.*

First of all I think it is imper­a­tive to real­ize that there is no such thing as a pure expe­ri­ence on only one cir­cuit. You’re con­stantly oper­at­ing at all
lev­els at all the time, it is just a mat­ter of focus­ing on one to reach the next level. For most peo­ple, talk­ing about any­thing beyond the sixth-circuit is
just going to seem silly, as real­ity becomes so skewed and out-of-this-world that there is absolutely no way to have a steady ref­er­ence point in rela­tion to
our every-day world.

The sixth cir­cuit is where a lot of progress is made con­cern­ing con­scious­ness, aware­ness, spir­i­tu­al­ity, or what have you. It’s an aware­ness of your aware­ness
that lets you choose who you want to be. Some would argue that this falls more in the realm of the 7th cir­cuit, but I dis­agree entirely. The 7th cir­cuit falls
more in the realm of the real­iza­tion of Self, or the union of para­dox­i­cal oppo­sites (yin/yang). All of that is still in the realm of the human, which the
8th cir­cuit com­pletely bypasses. How­ever, that’s besides the point…

Say you’ve been a white, male den­tist for the past ten years. You’re bored, dis­sat­is­fied, life has lost its fla­vor and you need to be revi­tal­ized. All of
your other cir­cuits are fine: you have a home, you’re healthy, you’re finan­cially sta­ble, you love to learn and talk, you have a dis­tinct moral/value
system…and every week­end you smoke so much high-quality cannabis that even the music on the radio sounds like a direct trans­mis­sion of divine ecstasy.

But that only takes you so far. You want more. You’re men­tally hun­gry for a new expe­ri­ence, a new ride, a new YOU. At this point some peo­ple have a mid-life
cri­sis, or con­vert to Chris­tian­ity while cry­ing about the pan­das, or maybe decide that actu­ally you’re homo­sex­ual. Who knows? But those kinds of rash
deci­sions rarely end well, they’re always the prod­uct of impul­sive­ness and irra­tional­ity that’s mis­placed. I know what you crave. It’s deep inside yr bones,
your very mar­row pro­duces it and yr loins throb with the lust for it.

You want High Adven­ture. You may not real­ize it, but some­thing inside you calls out for a wan­der­ing through sacred groves, call­ing upon hid­den spir­its. Or
maybe a trek through hell­ishly hot deserts and the shade of a hill. It’s not just a recon­nec­tion with nature, it’s a com­plete trans­for­ma­tion of Fan­tasy into
Real­ity. Some­thing out of a D&D role-playing adven­ture, except far more ballsy, and with far more purpose.

So are you ready then, brave adven­turer of…wherever? Pre­pare yr mind to take in Rizzo’s Sixth Cir­cuit Psy­che­delic Circus.

If done prop­erly, you will no longer be the same per­son you once were. That is to say, noth­ing will be taken away, except for the bound­aries of who you think
you can be. This is the arena of arche­typal fig­ures, of monks, mages, mag­is­trates, emper­ors, kings, queens, gods and god­desses. And you can be any of those,
as long as you truly become them. You can not approach this in a strictly ratio­nal, log­i­cal man­ner. What will take place is a fluid, intu­itive cre­ation of a
new “char­ac­ter”, so to speak. View your life as a story-book, where every­thing is entirely mythic in scale.

Before set­ting out on yr adven­ture it is best to first immerse yrself in the spirit of that which you wish to become. Gen­er­ally, I let the envi­ron­ment dic­tate
the arche­type that I take on, I don’t try to force any­thing onto the expe­ri­ence. If you’ve been liv­ing in the west yr entire life and yr ances­tors were all
Vikings raiders, it will be much more nat­ural to take on the role of maybe Thor or Odin or some berserker out to rape, rav­age, and pil­lage than an East­ern
samu­rai or monk or what have you. This should all be an expres­sion of yr inner­most love of fun, fan­tasy, and weirdness.

Read­ing fan­tasy or mythol­ogy can put one in the proper frame of mind, and give you a proper mental-vocabulary. Let’s say you, the den­tist, wishes to become a
great viking war­rior for a while. To do this you need to think of the world in the man­ner proper to that time – but not in a “his­tor­i­cally accu­rate” con­text.
Remem­ber, every­thing is now mythic, com­pletely epic in scope. The Gods are involved in every­thing you do and take part of. Every­thing in nature is teem­ing
with secrets and mys­ter­ies. That cave that you pass by? It’s home to dark-elves – or dwarves – who for the right price will fash­ion you an arti­fact of great
power. But beware! Loki, the trick­ster, will be out to con­fuse you the entire time…

Okay, so now you have a feel for the spirit and the ambiance of the world you’re about to enter. But how do you break through? How can you really con­vince
your­self that this is tak­ing place – espe­cially in this day and age? All these arti­fi­cial lights, machines, cars, noises, and what have you…It’s enough to
drain the fan­tasy and imag­i­na­tion out of even the most googly-eyed of seek­ers. I can not rec­om­mend any­thing spe­cific, how­ever I can tell you what works for
me.

Noth­ing will get you into the mood of adven­ture then really putting some­thing at stake. Pre­pare your­self for a real adven­ture, load up a back­pack with sim­ple
items like food, water, etc, and other objects that have spir­i­tual sig­nif­i­cance or are rel­e­vant. For exam­ple, as a viking war­rior you should obvi­ously have
some sort of weapon – but walk­ing around with a gigan­tic axe is a sure way to get locked up some­where. So per­haps carry a knife of legal size, or a walk­ing
stick – any­thing that you can use yr imag­i­na­tion to turn into an item of power. Hills will no longer be hills, but the gathering-place of the fairy-folk. At
some places, at some times, and the in the right frame of mind, even rocks will tell you their secrets. It might be con­ducive to imple­ment some sort of quest
into yr adven­ture so it is more than ran­dom wan­der­ing. Per­haps you’re seek­ing an object of power, the bless­ing of the gods, or secret wis­dom which can only
be had in a cer­tain loca­tion. There might be a med­i­cine you need to find that is only avail­able in a cer­tain place. You can really mix-and-match this sort of
stuff with every­day real­ity, where cash­ing a check becomes the raid­ing of an enemy village.

So, you’re pre­pared. You’re about to go hik­ing off into god’s know where, with the right frame of mind, the right equip­ment, and the intent to break­through
into another self. But it’s not so easy, even if you’re already well versed in circuit-jumping. While I’ve found that long jour­neys will always do the trick
of break­ing into that mythic feel­ing of god-hood, cer­tain chem­i­cals also help. Higher doses of DXM, mid-level dosages of mush­rooms, low-to-mid-dosages of
LSD, and many other psy­che­delics can help. It will take some exper­i­men­ta­tion to get prop­erly, but just about any­thing will work if you’ve pre­pared prop­erly
and really set off on an adven­ture. The only real dan­ger is per­haps going too far and land­ing in the 7th or even 8th cir­cuit and not being prepared.

Prac­tice makes perfect.

There’s no way to really describe what is going to hap­pen to you, because it will be intensely per­sonal and yet at the same time com­pletely void of that
ego-self-personality you know as “your­self”. At a cer­tain point you should get so lost in the thoughts and feel­ings of the Viking Wan­derer named Ugarth that
you’ll com­pletely for­get that you were a den­tist. Feel­ings of com­plete insan­ity, total detach­ment from real­ity, etc might start to over­whelm you. That’s
okay, we’re all crazy any­way. You’re just going crazy on pur­pose. But why?

To pro­duce a shock. When you sud­denly for­get that you were a den­tist, you’ll become Ugarth. But then you’ll remem­ber that you for­got, so you’ll have to
remem­ber you are – except that now you can’t relate to the thoughts and feel­ings of you the den­tist. A sud­den schism will occur where you are nei­ther Ugarth
nor the den­tist, and yet you are very much still you. It is at that moment, where you are nei­ther one nor the other, nei­ther up nor down, here nor there,
that you truly expe­ri­ence High Weird­ness. Who am I? For that mat­ter, WHAT am I, that I am able to change my self, have no self, and yet still at my very
essence always be my self? From there one can scale fur­ther on up into the 7th cir­cuit of cel­lu­lar & DNA/sexual con­scious­ness, use the 6th cir­cuit to mod­ify
the lower ones, or just play around with your new self.

At this point, either real­ity will seem valid, so you’ll be able to deal with both real­i­ties as you know them with ease. Once you’ve bro­ken through to that
level of uncer­tainty, Ugarth with nat­u­rally sur­face into your life. Hav­ing a viking war­rior for a den­tist could make for some very inter­est­ing inter­est­ing
con­ver­sa­tions on the topic of oral hygiene. After all, a true viking war­rior uses the blood of his ene­mies for mouth wash, and uses the fur of rein­deer to
brush his teeth.

Life should be much more fun now, and far less seri­ous. With cre­ative imag­i­na­tion, some psilo­cy­bin, and an adven­tur­ous spirit, you can turn the most mun­dane
of tasks into some­thing of truly epic pro­por­tions. Even study­ing at the library can be the intense search for hid­den knowl­edge of a scholar or philoso­pher.
Most impor­tantly, you won’t be cling­ing to those sorry ideas of who you think you are. Your entire self-image won’t be depen­dent upon these lame ter­res­trial
activ­i­ties and use­less busi­ness of busy-bodies that tell you that all to life is work, wife, and child.

No, it is no longer that way. Now you can look up at the sky as the sun-sets and say to your heart, “Tonight, I will take up bat­tle against the Giants and if
I should fall, may the Valkyries take me to Val­halla. Noth­ing would be more hon­or­able.” And as you get lost in the forest-park as you search for yr hated
foes, if the fairies should try to dis­tract you and entice you into strange games and sweet pleasures…

Tell them Rizzo sent you, and that you are on a quest. Laugh it off. After all, this is the Sixth Cir­cuit Psy­che­delic CIRCUS. Noth­ing is ever as it appears,
much less you. Take noth­ing seri­ously. Laugh with the might of one who is truly mythic in stature.

After all, is it not writ­ten, “I have said, Ye are Gods,”…?

Death, Dis­so­cia­tives, and Dumbness

Writ­ten while in a seri­ous ket­a­mine funk by Rizzo

There is a strange­ness which per­me­ates the uni­verse, a cer­tain alien qual­ity to the intel­li­gence of this weird mix of life and death that we call an adven­ture. Or at least I call it an adven­ture, or maybe more cor­rectly an infi­nite, never end­ing war. Either way, if I have indeed even split the ways (is there more than one?), the point is that I have found a way to har­ness this force. It now per­me­ates me, every­thing I do, speak, write, not-do, think about, NOT think about, dream, awake, remem­ber, for­get, what­ever, who­ever, whenever…why ever. Why, indeed? With­out the ques­tion there can be no answer, and with­out a self there can not be another.

So really, per­haps what I’m get­ting at is that there is no sep­a­rate­ness from this strange­ness of which per­me­ates me and every­thing – or rather there is no “me” but there is strange­ness and a uni­verse, in other terms there is only a “me” that is an infi­nitely strange uni­verse. If you’re con­fused, well, wel­come to my world. There’s noth­ing in it except con­fu­sion & strange­ness. Sorry to break it to you, if you were expect­ing a cir­cus and fire­works you should just load up on some dimethyl­trypt­a­mine, salvia divi­no­rum and have a blast at Fill­more on the 4th of July. Hell, that sounds like a great idea. Why haven’t I done that?

Maybe it’s because I’ve been too busy watch­ing every­thing around me slowly dying and being reborn, reshuf­fled, or reap­plied to a dif­fer­ent sec­tion of this quasi-universe. Mmm…another hit from my most favorite light bulb vapor­izer, per­haps the most ghetto way to get as much out of yr cannabis for as long as pos­si­ble. Stay high as pos­si­ble. For as long as pos­si­ble. Wait, was that what I was sent here for? Or just some strange side-trip on my big­ger jour­ney of life?

This is exactly what I was ask­ing myself as I laid in a bug-ridden tent in a river bot­tom, stuck in a K-hole, smacked out of my mind, with cannabi­noid recep­tors fir­ing and mis­fir­ing, implod­ing and explod­ing at such a hor­rific rate of speed that there was light, and darkness…Day, night…Sleep? No, of course not. What is that? Aren’t we already asleep? We wake up from one dream to fall asleep into another. The dreamer is the dreamed.

The screams of sex washed over my ear drums as my two trip­ping part­ners went at it in the neigh­bor­ing tent (there is a small com­mu­nity called bamboo/tent city). I couldn’t tell what was worse, their inces­sant bitch­ing at each other all night over any and every­thing, or their incred­i­bly over exag­ger­ated cries & moans of plea­sure & sexy what nots.

The ket­a­mine was weird, almost too weird but I couldn’t sep­a­rate myself from the weird­ness and I can’t very well call myself too weird, so it passed. There were strange beasts lurk­ing all about, hor­ri­ble mon­sters made of pure dark­ness and shadow, with fire and vengeance in their bot­tom­less, black holes of eyes. What could I do but retreat and wait until they were van­quished by the com­ing dawn?

And some­how I’m back at an Agent Orange show a few years ago…Halloween, with the “Misfits”….

Blood­stains, speed kills,

Fast cars, cheap thrills,

Rich girls, fine wine

I’ve lost sense – I’ve lost con­trol – I’ve lost my

Mind

Maybe that’s what I should have done. Started singing old punk songs and mosh­ing with the fuck­ers. Why not? Beasts from the nether­world know how to really jam.

Death…That’s why. Or maybe life is why. Death, death, death…I know you well, friend. Just in the last week or so you’ve paid a visit to two of my friends…subjects the rest of my friends hap­pened to be dwelling on. I never, ever know what to say to peo­ple who take the mat­ter of death harshly. How can you get all whiney and cry­ing & what not when you know that yr own death is right around the cor­ner? If it’s even that far off…

And what is it that we lose, any­way? Who is there to die?

Well, I sup­pose there are two peo­ple that were there now that aren’t here any­more – what­ever that means. One was stabbed to death over some petty pseudo-gang bull­shit, the other over­dosed shoot­ing heroin and was pushed into his father’s front lawn, stone dead. I know a spell, and it goes N-A-R-C-A-N. Oh well, what can one do against death?

Not that the peo­ple I was with ever asked those kinds of ques­tions. Sure, they ask the prover­bial stoner ques­tions, “Dude, do you think that any­thing is like, even real?” – but I have never seen one try to apply it to their life. “Well, my suf­fer­ing isn’t real so there’s no rea­son to com­plain, is there?”

Dumb­ness, dumb­ness all around me and not a sin­gle way to move. Trapped, like a hor­ri­ble, beady eye rat in a cage. Or mag­gots, bur­row­ing into yr skin…eating yr flesh.

But hell, what can I do? I’m an idiot, too.

I’m just weirder.

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